4 documents found, page 1 of 1
Diagnosis and treatment of chronic lymphocytic leukemia: recommendations from t...
Rodrigues,Celso Arrais; Gonçalves,Matheus Vescovi; Ikoma,Maura Rosane Valério; Lorand-Metze,Irene; Pereira,André DominguesABSTRACT Chronic lymphocytic leukemia is characterized by clonal proliferation and progressive accumulation of B-cell lymphocytes that typically express CD19+, CD5+ and CD23+. The lymphocytes usually infiltrate the bone marrow, peripheral blood, lymph nodes, and spleen. The diagnosis is established by immunophenotyping circulating B-lymphocytes, and prognosis is defined by two staging systems (Rai and Binet) es...
Hemoglobinúria paroxística noturna: da fisiopatologia ao tratamento
Arruda,Martha Mariana de Almeida Santos; Rodrigues,Celso Arrais; Yamamoto,Mihoko; Figueiredo,Maria StellaHemoglobinúria paroxística noturna (HPN) é uma anemia hemolítica crônica adquirida rara, de curso clínico extremamente variável. Apresenta-se frequentemente com infecções recorrentes, neutropenia e trombocitopenia, e surge em associação com outras doenças hematológicas, especialmente com síndromes de falência medular, como anemia aplásica e síndrome mielodisplásica. É considerada ainda um tipo de trombofilia ad...
Proliferating cell nuclear antigen (PCNA), p53 and MDM2 expression in Hodgkins...
Pinheiro,Gevina Silva; Silva,Maria Regina Régis; Rodrigues,Celso Arrais; Kerbauy,José; Oliveira,José Salvador Rodrigues deCONTEXT AND OBJECTIVE: Tumor cells in Hodgkins disease (HD) express cell proliferation markers that are evaluated according to the oncogenes involved or the expression of their proteins. Correlations between the protein expression grade and clinical data are now important for disease prognosis. DESIGN AND SETTING: This was a retrospective analysis on proliferating cell nuclear antigen (PCNA), p53 and MDM2 (mur...
Cerebral venous thrombosis and hepatitis: case report
Felício,André Carvalho; Fukujima,Márcia Maiumi; Fiorot Jr,Jose Antônio; Prado,Gilmar Fernandes do; Carvalho Filho,Roberto José deAmong the many infective causes of cerebral venous thrombosis (CVT), viral hepatitis is been regarded as a rare associated condition. We report on a 56-years-old man presenting CVT associated with hepatitis B and C coinfections outlining probable pathogenic mechanisms. We suggest that virus B and C serology should be performed in the cases of cerebral venous thrombosis with unknown etiology.