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OPPOSITE MODULATION OF ASTROGLIAL PROLIFERATION BY ADENOSINE 5 '-O-(2-THIO)-DIP...

Quintas, C; Fraga, S; Goncalves, J; Queiroz, G

The contribution of P2Y(12,13) receptors to astroglial proliferation was investigated by testing the effects of two agonists with high affinity for these receptors, adenosine 5'-O-(2-thio)-diphosphate (ADP beta S) and 2-methylthioadenosine-5'-diphosphate (2-MeSADP), in the incorporation of [H-3]-thymidine. The effect of ATP, an endogenous inducer of astroglial proliferation, was also investigated. ADP beta S an...


Interaction between adenosine A(2B)-receptors and alpha(2)-adrenoceptors on the...

Talaia, C; Queiroz, G; Quintas, C; Goncalves, J

In the prostatic portion of rat vas deferens, activation of adenosine A(2B)-receptors, beta(2)-adrenoceptors, adenylyl cyclase or protein kinase A caused a facilitation of noradrenaline release. Blockade of alpha(2)-adrenoceptors with yohimbine (1 mu M) attenuated the facilitation mediated by adenosine A(2B)-receptors and by direct activation of adenylyl cyclase with forskolin but not that mediated by beta(2)-a...


Coupling to protein kinases A and C of adenosine A(2B) receptors involved in th...

Queiroz, G; Quintas, C; Talaia, C; Goncalves, J

In the prostatic portion of rat vas deferens, the non-selective adenosine receptor agonist NECA (0.1-30 muM), but not the A(2A) agonist CGS 21680 (0.001-10 muM), caused a facilitation of electrically evoked noradrenaline release (up to 43 +/- 4%), when inhibitory adenosine A(1) receptors were blocked. NECA-elicited facilitation of noradrenaline release was prevented by the A,B receptor-antagonist MRS 1754, enha...


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