The contribution of P2Y(12,13) receptors to astroglial proliferation was investigated by testing the effects of two agonists with high affinity for these receptors, adenosine 5'-O-(2-thio)-diphosphate (ADP beta S) and 2-methylthioadenosine-5'-diphosphate (2-MeSADP), in the incorporation of [H-3]-thymidine. The effect of ATP, an endogenous inducer of astroglial proliferation, was also investigated. ADP beta S an...
In the prostatic portion of rat vas deferens, activation of adenosine A(2B)-receptors, beta(2)-adrenoceptors, adenylyl cyclase or protein kinase A caused a facilitation of noradrenaline release. Blockade of alpha(2)-adrenoceptors with yohimbine (1 mu M) attenuated the facilitation mediated by adenosine A(2B)-receptors and by direct activation of adenylyl cyclase with forskolin but not that mediated by beta(2)-a...
In the prostatic portion of rat vas deferens, the non-selective adenosine receptor agonist NECA (0.1-30 muM), but not the A(2A) agonist CGS 21680 (0.001-10 muM), caused a facilitation of electrically evoked noradrenaline release (up to 43 +/- 4%), when inhibitory adenosine A(1) receptors were blocked. NECA-elicited facilitation of noradrenaline release was prevented by the A,B receptor-antagonist MRS 1754, enha...