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Ética no Tratamento da Dor na População Pediátrica

Pinto-Coelho, A; Trindade, H

A prescrição off label de fármacos analgésicos na população pediátrica constituí uma realidade incontornável nos sistemas de saúde modernos. Os medicamentos são usados em off label quando são empregues fora dos termos da licença do produto, nomeadamente no que respeita ao grupo etário, à idade, ao peso, à frequência de uso, à apresentação ou à via de administração. Por questões éticas, a elaboração de ensaios c...


The Airway Approach to a Neonate with Treacher Collins Syndrome. Case Report

Marques-Pires, R; Trindade, H

Neonates and small infants with syndromes characterized by the presence of craniofacial abnormalities may represent great challenges regarding the management of the airway. We describe the case of a 9-day-old neonate with Treacher Collins syndrome, in which a laryngeal mask was essential to improve the airway obstruction, ventilate the patient and serve as an airway conduit for a fiberoptic intubation. By prese...


Clinical Outcomes and Genetic Expression Profile in Human Liver Graft Dysfuncti...

Paulino, J; Vigia, E; Marcelino, P; Abade, O; Sobral, J; Ligeiro, D; Carvalho, A; Alves, M; Papoila, AL; Trindade, H; Barroso, E

Introduction. This study aims to compare the molecular gene expression during ischemia reperfusion injury. Several surgical times were considered: in the beginning of the harvesting (T0), at the end of the cold ischemia period (T1), and after reperfusion (T2) and compared with graft dysfunction after liver transplant (OLT). Methods. We studied 54 patients undergoing OLT. Clinical, laboratory data, and histologi...


Rice (Oryza sativa L.) phenolic compounds under elevated carbon dioxide (CO2) c...

Goufo, P.; Pereira, J.; Moutinho-Pereira, J.; Correia, C.; Figueiredo, N.; Carranca, C.; Rosa, E.; Trindade, H

Previous studies have shown that elevated levels of carbon dioxide [CO2] may increase, decrease, or have no effect on the concentrations of phenolic compounds in plants. The underlying causes of these variations in responses remain poorly understood. In the present study, it was hypothesized that different plant responses come mainly from the duration of exposure to the gas, growing conditions, and sampling pro...


Transplant glomerulopathy: clinico-pathologic features

Silva, C; Cotovio, P; Marques, M; Afonso, N; Sancho, MR; Carvalho, F; Trindade, H; Carreira, A; Campos, M; Nolasco, F

Transplant glomerulopathy is a sign of chronic kidney allograft damage. It has a distinct morphology and is associated with poor allograft survival. We aimed to assess the prevalence and clinic-pathologic features of transplant glomerulopathy, as well as determine the functional and histological implications of its severity. We performed a single-centre retrospective observational study during an eight-year per...


Transplant Glomerulopathy: Clinico-Pathologic Features

Silva, C; Cotovio, P; Marques, M; Afonso, N; Sancho, MR; Carvalho, F; Trindade, H; Carreira, A; Campos, M; Nolasco, F

Transplant glomerulopathy is a sign of chronic kidney allograft damage. It has a distinct morphology and is associated with poor allograft survival. We aimed to assess the prevalence and clinic-pathologic features of transplant glomerulopathy, as well as determine the functional and histological implications of its severity. We performed a single-centre retrospective observational study during an eight-year per...


Técnicas de Anestesia Regional em Cirurgia Ortopédica Pediátrica - Estudo Retro...

Carneiro, A; Rodrigues, A; Trindade, H; Pires, R

A anestesia regional em ortopedia apresenta vantagens claras na estabilidade hemodinâmica, perfusão do território cirúrgico e analgesia de qualidade superior. o objectivo deste estudo foi avaliar o tipo e frequência de técnicas realizadas no ano de 2012 em anestesia para cirurgia ortopédica pediátrica. Um total de 662 crianças agendadas para cirurgia electiva foram retrospectivamente estudadas no que diz respei...


Prevalence of HLA antibodies in post pregnancies female blood donors

Barra, A; Barradas, A; Cardoso, E; Costa, C; Fontes, A; Gil, A; Oliveira, C; Ramalhete, L; Rodrigues, T; Sancho, MR; Silva, I; Simões, A; Trindade, H

Background: Transfusion related acute lung injury (TRALI) is known as transfusion hazard with high morbidity and mortality rate. Mainly HLA class II have been associated with TRALI. Preventive measures are in the exclusion of donor female as they carry any these antibodies. Aim: We study a group of female blood donor with prior history of two or more pregnancies (G2), one (G1) pregnancy and without any pregnanc...


Transplantation in Highly Sensitised Patients Treated with Intravenous Immunogl...

Ferreira, AC; Brum, S; Fernandes, V; Buinho, F; Viana, H; Alcântara, P; Ferreira, A; Candeias, N; Sousa, J; Lima, A; Carvalho, F; Trindade, H

Renal transplant in highly sensitised patients is associated with increased morbidity. The aim of this retrospective study was to evaluate the clinical evolution of 30 highly sensitised deceased donor kidney transplants and the influence of different timing of B cell directed treatment and its importance in the outcome of these patients. All recipients had negative complement dependent lymphocytotoxicity cytoto...


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