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Impact of white-matter mask selection on DTI histogram-based metrics as potenti...

Rodrigues Fouto, Ana Lúcia; Nunes, Rita G.; Pinto, Joana; Alves, Luísa; Calado, Sofia; Gonçalves, Carina; Rebolo, Margarida; Viana Baptista, Miguel

Objective: Histogram-based metrics extracted from diffusion-tensor imaging (DTI) have been suggested as potential biomarkers for cerebral small vessel disease (SVD), but methods and results have varied across studies. This work aims to assess the impact of mask selection for extracting histogram-based metrics of fractional anisotropy (FA) and mean diffusivity (MD) on their sensitivity as SVD biomarkers. Methods...


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