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Antihypertensive effect of spent brewer yeast peptide

Amorim, M.; Marques, C.; Pereira, J. O.; Guardão, L.; Martins, M. J.; Osório, H.; Moura, D.; Calhau, C.; Pinheiro, H.; Pintado, M.

Numerous studies have investigated dietary approaches to prevent chronic lifestyle-related diseases, including hypertension. Spent brewer's yeast is the second largest byproduct originated by the brewing industry and it deserves considerable attention because of its high nutritional value, ca. 40% of its dry mass is rich in protein which can be hydrolyzed into biologically active peptides. To upgrade this bypro...


Germline mutations in MAP3K6 are associated with familial gastric cancer

Gaston, D.; Hansford, S.; Oliveira, C.; Nightingale, M.; Pinheiro, H.; Macgillivray, C.; Kaurah, P.; Rideout, A.; Steele, P.; Soares, G.; Huang, W.

Gastric cancer is among the leading causes of cancer-related deaths worldwide. While heritable forms of gastric cancer are relatively rare, identifying the genes responsible for such cases can inform diagnosis and treatment for both hereditary and sporadic cases of gastric cancer. Mutations in the E-cadherin gene, CDH1, account for 40% of the most common form of familial gastric cancer (FGC), hereditary diffuse...


Optical fiber bioanalyzer based on enzymatic coating matrix for catecholamines ...

Silva, Lurdes I. B.; Gomes, A. M.; Pintado, M. M.; Pinheiro, H.; Moura, D.; Freitas, Ana C.; Rocha-Santos, Teresa A. P.; Pereira, M. E.; Duarte, A. C.

The urinary levels of catecholamines [adrenaline (AD), noradrenaline (NA), and dopamine (DA)] and their metabolites [L-3,4-dihydroxyphenylalanine (L-DOPA), and 3,4-dihydroxyphenylacetic acid (DOPAC)], as indicators of physiological stress, were assessed in 40 patients with Down syndrome (DS). The analysis was performed by an optical fiber (OF) bioanalyzer; which was constituted by two main components: a miniatu...


Optical fiber bioanalyzer based on enzymatic coating matrix for catecholamines ...

Silva, Lurdes I. B.; Gomes, A. M.; Pintado, M. M.; Pinheiro, H.; Moura, D.; Freitas, Ana C.; Rocha-Santos, Teresa A. P.; Pereira, M. E.; Duarte, A. C.

The urinary levels of catecholamines [adrenaline (AD), noradrenaline (NA), and dopamine (DA)] and their metabolites [L-3,4-dihydroxyphenylalanine (L-DOPA), and 3,4-dihydroxyphenylacetic acid (DOPAC)], as indicators of physiological stress, were assessed in 40 patients with Down syndrome (DS). The analysis was performed by an optical fiber (OF) bioanalyzer; which was constituted by two main components: a miniatu...


Potency of AT(1) receptor antagonists to block angiotensin II-evoked increase i...

Pinheiro, H.; Moura, D.; Viegas, Olga; Calhau, Conceição; Guimarães, S.

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