7 documents found, page 1 of 1
DNA methyltransferase expression (DNMT1, DNMT3a, and DNMT3b) as a potential bio...
Camacho, Pedro; Ribeiro, Edna; Pereira, Bruno; Nascimento, João; Rosa, Paulo Caldeira; Henriques, José; Barrão, Sandra; Sadio, Silvia; Quendera, BrunoBackground/Objectives: Age-related macular degeneration (AMD) is a global cause of vision loss, with limited therapeutic options highlighting the need for effective biomarkers. This study aimed to characterize plasma DNA methyltransferase expression (DNMT1, DNMT3A, and DNMT3B) in AMD patients and explore divergent expression patterns across different stages of AMD. Methods: Thirty-eight AMD patients were prospe...
DNA Methyltransferase Expression (DNMT1, DNMT3a, and DNMT3b) as a Potential Bio...
Camacho, Pedro; Ribeiro, Edna; Pereira, Bruno; Nascimento, João; Caldeira Rosa, Paulo; Henriques, José; Barrão, Sandra; Sadio, Silvia; Quendera, BrunoAge-related macular degeneration (AMD) is a global cause of vision loss, with limited therapeutic options highlighting the need for effective biomarkers. This study aimed to characterize plasma DNA methyltransferase expression (, , and ) in AMD patients and explore divergent expression patterns across different stages of AMD. : Thirty-eight AMD patients were prospectively enrolled and stratified by disease seve...
The neurometabolic profiles of GABA and Glutamate as revealed by proton magneti...
d'Almeida, Otília C.; Violante, Inês R.; Quendera, Bruno; Moreno, Carolina; Gomes, Leonor; Castelo-Branco, MiguelGlucose metabolism is pivotal for energy and neurotransmitter synthesis and homeostasis, particularly in Glutamate and GABA systems. In turn, the stringent control of inhibitory/excitatory tonus is known to be relevant in neuropsychiatric conditions. Glutamatergic neurotransmission dominates excitatory synaptic functions and is involved in plasticity and excitotoxicity. GABAergic neurochemistry underlies inhibi...
Enhanced Visual Attentional Modulation in Patients with Inherited Peripheral Re...
Ferreira, Sónia; Pereira, Andreia Carvalho; Quendera, Bruno; Reis, Aldina; Silva, Eduardo Duarte; Castelo-Branco, MiguelThe role of attentional mechanisms in peripheral vision loss remains an outstanding question. Our study was aimed at determining the effect of genetically determined peripheral retinal dystrophy caused by Retinitis Pigmentosa (RP) on visual cortical function and tested the recruitment of attentional mechanisms using functional magnetic resonance imaging (fMRI). We included thirteen patients and twenty-two age- ...
Primary visual cortical remapping in patients with inherited peripheral retinal...
Ferreira, Sónia; Pereira, Andreia Carvalho; Quendera, Bruno; Reis, Aldina; Silva, Eduardo Duarte; Castelo-Branco, MiguelHuman studies addressing the long-term effects of peripheral retinal degeneration on visual cortical function and structure are scarce. Here we investigated this question in patients with Retinitis Pigmentosa (RP), a genetic condition leading to peripheral visual degeneration. We acquired functional and anatomical magnetic resonance data from thirteen patients with different levels of visual loss and twenty-two...
Structure-function correlations in Retinitis Pigmentosa patients with partially...
Machado, Ana Rita; Pereira, Andreia Carvalho; Ferreira, Fábio; Ferreira, Sónia; Quendera, Bruno; Silva, Eduardo; Castelo-Branco, MiguelRetinitis Pigmentosa is a group of hereditary retinal dystrophy disorders associated with progressive peripheral visual field loss. The impact of this retinal loss in cortical gray matter volume has not been addressed before in Retinitis Pigmentosa patients with low vision. Voxel-based morphometry was applied to study whole brain gray matter volume changes in 27 Retinitis Pigmentosa patients with partially pres...
Relations between Cardiac and Visual Phenotypes in Diabetes: A Multivariate App...
Oliveiros, Bárbara; Sanches, Mafalda; Quendera, Bruno; Graça, Bruno; Guelho, Daniela; Gomes, Leonor; Carrilho, Francisco; Alves, Filipe CaseiroCardiovascular disease and diabetes represent a major public health concern. The former is the most frequent cause of death and disability in patients with type 2 diabetes, where left ventricular dysfunction is highly prevalent. Moreover, diabetic retinopathy is becoming a dominant cause of visual impairment and blindness. The complex relation between cardiovascular disease and diabetic retinopathy as a functio...