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Antibiotic residues in final effluents of European wastewater treatment plants ...

Rodriguez-Mozaz, Sara; Vaz-Moreira, Ivone; Varela Della Giustina, Saulo; Llorca, Marta; Barceló, Damia; Schubert, Sara; Berendonk, Thomas U.

A comprehensive monitoring of a broad set of antibiotics in the final effluent of wastewater treatment plants (WWTPs) of 7 European countries (Portugal, Spain, Ireland, Cyprus, Germany, Finland, and Norway) was carried out in two consecutive years (2015 and 2016). This is the first study of this kind performed at an international level. Within the 53 antibiotics monitored 17 were detected at least once in the f...


A global multinational survey of cefotaxime-resistant coliforms in urban wastew...

Marano, Roberto B. M.; Fernandes, Telma; Manaia, Célia M.; Nunes, Olga; Morrison, Donald; Berendonk, Thomas U.; Kreuzinger, Norbert; Tenson, Tanel

The World Health Organization Global Action Plan recommends integrated surveillance programs as crucial strategies for monitoring antibiotic resistance. Although several national surveillance programs are in place for clinical and veterinary settings, no such schemes exist for monitoring antibiotic-resistant bacteria in the environment. In this transnational study, we developed, validated, and tested a low-cost...


Antibiotic residues in final effluents of european wastewater treatment plants ...

Rodriguez-Mozaz, Sara; Vaz-Moreira, Ivone; Giustina, Saulo Varela Della; Llorca, Marta; Barceló, Damià; Schubert, Sara Schubert; Manaia, Celia M.

A comprehensive monitoring of a broad set of antibiotics in the final effluent of wastewater treatment plants (WWTPs) of 7 European countries (Portugal, Spain, Ireland, Cyprus, Germany, Finland, and Norway) was carried out in two consecutive years (2015 and 2016). This is the first study of this kind performed at an international level. Within the 53 antibiotics monitored 17 were detected at least once in the f...


A global multinational survey of cefotaxime-resistant coliforms in urban wastew...

Marano, Roberto B.M.; Fernandes, Telma; Manaia, Célia M.; Nunes, Olga; Morrison, Donald; Berendonk, Thomas U.; Kreuzinger, Norbert; Tenson, Tanel

The World Health Organization Global Action Plan recommends integrated surveillance programs as crucial strategies for monitoring antibiotic resistance. Although several national surveillance programs are in place for clinical and veterinary settings, no such schemes exist for monitoring antibiotic-resistant bacteria in the environment. In this transnational study, we developed, validated, and tested a low-cost...


Antibiotic resistance in European wastewater treatment plants mirrors the patte...

Pärnänen, Katariina M. M.; Narciso-da-Rocha, Carlos; Kneis, David; Berendonk, Thomas U.; Cacace, Damiano; Do, Thi Thuy; Elpers, Christian

Integrated antibiotic resistance (AR) surveillance is one of the objectives of the World Health Organization global action plan on antimicrobial resistance. Urban wastewater treatment plants (UWTPs) are among the most important receptors and sources of environmental AR. On the basis of the consistent observation of an increasing north-to-south clinical AR prevalence in Europe, this study compared the influent a...


Antidepressants in a changing ocean: Venlafaxine uptake and elimination in juve...

Luísa Maulvault, Ana; Santos, Lúcia H.M.L.M.; Camacho, Carolina; Anacleto, Patrícia; Barbosa, Vera; Alves, Ricardo; Pousão Ferreira, Pedro

The presence of antidepressants, such as venlafaxine (VFX), in marine ecosystems is increasing, thus, potentially posing ecological and human health risks. The inherent mechanisms of VFX uptake and elimination still require further understanding, particularly accounting for the impact of climate change-related stressors, such as warming and acidification. Hence, the present work aimed to investigate, for the fi...


Differential behavioural responses to venlafaxine exposure route, warming and a...

Luísa Maulvault, Ana; Santos, Lúcia H.M.L.M.; Paula, José Ricardo; Camacho, Carolina; Pissarra, Vasco; Fogaça, Fabiola; Barbosa, Vera; Alves, Ricardo

Antidepressants, such as venlafaxine (VFX), which are considered emerging environmental pollutants, are increasingly more present in the marine environment, and recent evidence suggest that they might have adverse effects on fish behaviour. Furthermore, altered environmental conditions associated to climate change (e.g. warming and acidification) can also have a determinant role on fish behaviour, fitness and s...


Differential gene transcription, biochemical responses, and cytotoxicity assess...

Serrano, Miguel A. S.; Gonzalez-Rey, Maria; Mattos, Jacó J.; Flores-Nunes, Fabrício; Mello, Álvaro C. P.; Zacchi, Flávia L.; Piazza, Clei E.

Pharmaceuticals, such as anti-inflammatory nonsteroidal drugs, are frequently detected in aquatic ecosystems. Studies about the effects of these substances in nontarget organisms, such as bivalves, are relevant. The aim of this study was to evaluate the effects on antioxidant status caused by ibuprofen (IBU) in oysters Crassostrea gigas exposed for 1, 4, and 7 days at concentrations 1 and 100 μg L(-1). Levels o...


Contribution of hospital effluents to the load of pharmaceuticals in urban wast...

Santos, Lúcia; Gros, Meritxell; Rodriguez-Mozaz, Sara; Delerue-Matos, Cristina; Pena, Angelina; Barceló, Damià; Montenegro, M. Conceição B. S. M.

The impact of effluent wastewaters from four different hospitals: a university (1456 beds), a general (350 beds), a pediatric (110 beds) and a maternity hospital (96 beds), which are conveyed to the same wastewater treatment plant (WWTP), was evaluated in the receiving urban wastewaters. The occurrence of 78 pharmaceuticals belonging to several therapeutic classes was assessed in hospital effluents and WWTP was...


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