13 documents found, page 1 of 2
World Heart Federation Cholesterol Roadmap: The Portuguese case
Abreu, A; Dores, H; Gonçalves, L; Franco, F; Silveira, C; Proença, G; Teresa Timóteo, A; Cardim, N; Pedro, M; Fiuza, M; Ferreira, D; Bento, LAtherosclerotic cardiovascular disease (ASCVD) remains the major cause of premature death and disability; effective cardiovascular (CV) risk prevention is fundamental. The World Heart Federation (WHF) Cholesterol Roadmap provides a framework for national policy development and aims to achieve ASCVD prevention. At the invitation of the WHF, a group of experts from the Portuguese Society of Cardiology (SPC), addr...
Effects and Mechanisms of Action of Preussin, a Marine Fungal Metabolite, again...
Seabra, R; Malhão, F; Correia, A; Costa, C; Kijjoa, A; Rocha, ETriple-negative breast cancer (TNBC) represents an aggressive subtype of breast cancer (BC) with a typically poorer prognosis than other subtypes of BC and limited therapeutic options. Therefore, new drugs would be particularly welcome to help treat TNBC. Preussin, isolated from the marine sponge-associated fungus, Aspergillus candidus, has shown the potential to reduce cell viability and proliferation as well ...
Fucoxanthin Holds Potential to Become a Drug Adjuvant in Breast Cancer Treatmen...
Malhão, F; Macedo, AC; Costa, C; Rocha, E; Ramos, AAFucoxanthin (Fx) is a carotenoid derived from marine organisms that exhibits anticancer activities. However, its role as a potential drug adjuvant in breast cancer (BC) treatment is still poorly explored. Firstly, this study investigated the cytotoxic effects of Fx alone and combined with doxorubicin (Dox) and cisplatin (Cis) on a panel of 2D-cultured BC cell lines (MCF7, SKBR3 and MDA-MB-231) and one non-tumor...
Effect of in vitro exposure to lead chloride on semen quality and sperm DNA fra...
Gomes, M; Goncalves, A; Rocha, E; Sa, R; Alves, A; Silva, J; Barros, A; Pereira, M L; Sousa, MExposure to lead may cause changes in the male reproductive system. We evaluated the effect of lead chloride (PbCl2) in vitro on semen quality from 31 individuals. Samples were incubated at room temperature for two exposure times (4 h and 8 h) and with two concentrations of PbCl2 (15 !g/ml or 30 !g/ml). Results showed that PbCl2 significantly inhibited rapid progressive motility and caused an increase in the pe...
Caspase signalling pathways in human spermatogenesis
Almeida, C; Correia, S; Rocha, E; Alves, A; Ferraz, L; Silva, JPurpose: Little is known about the apoptotic mechanisms involved in abnormal spermatogenesis. In order to describe the significance of apoptosis in azoospermia, testicular tissue from abnormal spermatogenesis was analysed. Methods: Testicular treatment biopsies were obtained from 27 men. Five presented oligozoospermia, 9 obstructive azoospermia (4 congenital bilateral absence of the vas deferens; 5 secondary az...
Expression of the myosin light chains 1, 2 and 3 in the muscle of blackspot sea...
Silva, P; Power, DM; Valente, LMP; Silva, N; Monteiro, RAF; Rocha, EPrevious studies on the histochemistry and immunoreactivity of fibres in lateral muscle of blackspot seabream indicated that there is a developmental transition in the composition of myofibnllar proteins, which presumably reflects changes in contractile function as the fish grows We hypothesize that the phenomenon underscores age and spatial differences in the expression of myosin light chains (MLC), not studie...
Hyperplastic and hypertrophic growth of lateral muscle in blackspot seabream Pa...
Silva, P; Valente, LMP; Olmedo, M; Galante, MH; Monteiro, RAF; Rocha, ETo understand better the growth mechanisms in the economically important fish Pagellus bogaraveo, in terms of muscle fibre hyperplasia v. hypertrophy, the lateral muscle of this fish was studied morphometrically from hatching to juvenile comparing rostral and caudal locations. Fish were sampled at 0, 5, 23, 40, 70, 100, 140 and 180 days. Fibre types were first identified by succinate dehydrogenase (SDH) and imm...
Dietary protein content influences both growth and size distribution of anterio...
Silva, P; Valente, LMP; Galante, MH; Andrade, CAP; Monteiro, RAF; Rocha, EMuscle cellularity was studied in Pagellus bogaraveo juveniles fed on diets with different protein contents. Measured in transversal body sections, at both post-opercular and post-anal locations, the morphometric variables estimated were: total muscle area (A), total number of fibres (N), number of fibres per unit area of muscle (N(A)) and cross-sectional fibre area ((a) over bar), of the two main muscle fibre ...
Muscle differentiation in blackspot seabream (Pagellus bogaraveo, Brunnich): Hi...
Silva, P; Rowlerson, AM; Valente, LMP; Olmedo, M; Monteiro, RAF; Rocha, EThe aim of this work was to gain insights into the mechanism of muscle differentiation and growth in Pagellus bogaraveo, by studying Muscle fibre phenotypes identified by immunohistochemistry. At hatching, several layers of deep fast-white fibres were covered by a superficial fibre monolayer. At 5 days, slow-red fibres appeared near the lateral line nerve. At 40 days, the intermediate-pink muscle became visible...
Breastfeeding: prevalence and determinant factors.
Sandes, Ana Rita; Nascimento, C; Figueira, J; Gouveia, R; Valente, S; Martins, S; Correia, S; Rocha, E; Da Silva, L JBreastfeeding is the best way of feeding the baby for the first six months of life. However, in Portugal the abandonment rate of breastfeeding is very high during the baby first's months of life. The aim of this study was to assess prevalence of breastfeeding and to identify related factors during the six months after delivery, as socio demographic variables and life styles. We conducted a cohort study at the M...