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Electrospun polycaprolactone membranes functionalized with nanochitin for enhan...

Costa, Sofia M.; Mattos, Bruno D.; Calhelha, Ricardo C.; Zhu, Ya; Lima, Eurico; Reis, Lucinda; Rojas, Orlando J.; Fangueiro, Raul; Ferreira, Diana P.

The encapsulation of photosensitizers (PSs) in electrospun membranes has emerged as a promising approach in photodynamic therapy (PDT) on tumor sites, overcoming the drawbacks associated with systemic administration. In this work, localized implants for cancer treatment using PDT were developed by incorporating EL-2 squaraine into poly(epsilon-caprolactone) (PCL) electrospun microfibers. The latter were coated ...

Date: 2025   |   Origin: Biblioteca Digital do IPB

Electrospun polycaprolactone membranes functionalized with nanochitin for enhan...

Costa, Sofia Maria Soares; Mattos, Bruno D.; Calhelha, Ricardo C.; Zhu, Ya; Lima, Eurico; Reis, Lucinda V.; Rojas, Orlando J.; Fangueiro, Raúl

The encapsulation of photosensitizers (PSs) in electrospun membranes has emerged as a promising approach in photodynamic therapy (PDT) on tumor sites, overcoming the drawbacks associated with systemic administration. In this work, localized implants for cancer treatment using PDT were developed by incorporating EL-2 squaraine into poly(ɛ-caprolactone) (PCL) electrospun microfibers. The latter were coated with c...


Regenerated cellulose properties tailored for optimized triboelectric output an...

Dahlström, Christina; Eivazi, Alireza; Nejström, Malin; Zhang, Renyun; Pettersson, Torbjörn; Iftikhar, Haider; Rojas, Orlando J.; Medronho, Bruno

Cellulose has shown great potential in the development of green triboelectric nanogenerators. Particularly, regenerated cellulose (R-cellulose) has shown remarkably high output power density but the structural features and key parameters that explain such superior performance remain unexplored. In this work, wood cellulose fibers were dissolved in a LiOH(aq)-based solvent to produce a series of R-cellulose film...


In-situ glyoxalization during biosynthesis of bacterial cellulose

Castro, Cristina; Cordeiro, Nereida; Faria, Marisa; Zuluaga, Robin; Putaux, Jean-Luc; Filpponen, Ilari; Velez, Lina; Rojas, Orlando J.; Gañán, Piedad

A novel method to synthesize highly crosslinked bacterial cellulose (BC) is reported. The glyoxalization is started in-situ, in the culture medium during biosynthesis of cellulose by Gluconacetobacter medellensis bacteria. Strong crosslinked networks were formed in the contact areas between extruded cellulose ribbons by reaction with the glyoxal precursors. The crystalline structure of cellulose was preserved w...


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