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Transcription factor NRF2 controls the fate of neural stem cells in the subgran...

Robledinos-Antón, Natalia; Rojo, Ana I; Ferreiro, Elisabete; Núñez, Ángel; Krause, Karl-Heinz; Jaquet, Vincent; Cuadrado, Antonio

Neural stem/progenitor cells (NSPCs) located at the subgranular zone (SGZ) of the hippocampus participate in the maintenance of synaptic networks that ensure cognitive functions during life. Although it is known that this neurogenic niche losses activity with oxidative stress and ageing, the molecular events involved in its regulation are largely unknown. Here, we studied the role of transcription factor Nuclea...

Date: 2017   |   Origin: Estudo Geral - Universidade de Coimbra
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