2 documents found, page 1 of 1
Rapid and efficient synthesis of α(1 – 2) mannobiosides.
Reina, José Juan; Maio, Antonio Di; Ramos Soriano, Javier; Figueiredo, Rute Cunha; Rojo Marcos, Francisco Javierα(1,2) mannobiosides with different substituents at the reducing end have been synthesized by a common strategy using benzoyls as the permanent protecting groups and an acetyl as the orthogonal protecting group at position C2 of the glycosyl acceptor. The new synthetic strategy has been performed remarkably reducing the number of purification steps, the time of synthesis (less than 72 hours) and improving the o...
Síntese de b-D-galactopiranosídeos de arila diméricos para avaliação de sua int...
Figueiredo, Rute Cunha; Meyer, Nádia Burkowski; Prado, Maria Auxiliadora Fontes; Rojo Marcos, Francisco JavierThe synthesis of two new D-galactose-based dimers having a 1,4-butanediamine spacer is reported aiming at the evaluation of their interaction with the Erythrina cristagalli lectin. The title compounds were prepared in four and five steps from 2,3,4,6-tetra-O-acetyl-b-D-galactopyranoside bromide, in 20 % and 15 % overall yield, respectively, using the Doebner modification of the Koenavenagel reaction as the key ...