5 documents found, page 1 of 1
Modulating inflammation through the neutralization of Interleukin-6 and tumor n...
Lima, Ana Cláudia Fernandes; Amorim, Diana Alexandra Silva; Laranjeira, Inês; Almeida, Armando; Reis, R. L.; Ferreira, Helena Susana Costa MachadoBiological agents that neutralize the activity of pro-inflammatory cytokines are revolutionizing the treatment of inflammatory conditions. However, the antibodies (Abs) short half-life and off-target distribution critically limit their efficacy and safety. Therefore, this work proposes the immobilization of anti-TNF-α and anti-IL-6 Abs at the surface of polymeric nanoparticles (NPs) in order to extend and incr...
O T H E R V I S U A L : Onto the Audiovisual Cooking
Laranjeira, Inês; Mota, João António de AlmeidaThis paper inquiries about the kitchen as space of vibrant materiality for representation and agency for art, design and architecture practices. On meeting the challenges posed by the coronavirus pandemic, it is not incidental that the 5th Istanbul Design Biennial curated by Mariana Pestana under the theme “Empathy Revisited: designs for more than one” has chosen the kitchen as a means to create spaces of disco...
O T H E R V I S U A L : onto the audiovisual cooking
Laranjeira, Inês; Mota, João A.This paper inquiries about the kitchen as space of vibrant materiality for representation and agency for art, design and architecture practices. On meeting the challenges posed by the coronavirus pandemic, it is not incidental that the 5th Istanbul Design Biennial curated by Mariana Pestana under the theme “Empathy Revisited: designs for more than one” has chosen the kitchen as a means to create spaces of disco...
Baccharis dracunculifolia decreases nociception, depressive-like behaviour and ...
Laranjeira, Inês; Apolinário, Elisabete; Amorim, Diana Alexandra Silva; Silva-Filho, Ademar; Pinto-Ribeiro, Filipa; Dias, Alberto Carlos PiresBackground: In arthritic disorders, inflammation and progressive degeneration of joints leads to the development of persistent pain and comorbid emotional impairments. Arthritis-induced peripheral sensitization leads to increased release of nociceptive molecules by primary afferents that activate neurones eglial cells in the spinal cord and supraspinal pain modulatory areas such as the amygdala (AMY) and the pe...
Baccharis dracunculifolia decreases nociception, depressive-like behaviour and ...
Laranjeira, Inês; Apolinário, Elisabete; Amorim, Diana Alexandra Silva; Silva-Filho, Ademar; Pinto-Ribeiro, Filipa; Dias, Alberto Carlos PiresIn arthritic disorders both inflammation and the progressive degeneration of joints persistently activate nociceptors, in periarticular structures, leading to the development of persistent pain and comorbid emotional impairments. Arthritis-induced peripheral sensitization leads to increased release of nociceptive molecules by primary afferents that activate neurones e glial cells in the spinal cord and supraspi...