8 documents found, page 1 of 1
Invasive infection due to Saprochaete capitata in a young patient with hematolo...
Parahym,Ana Maria Rabelo de Carvalho; Rolim Neto,Pedro José; Silva,Carolina Maria da; Domingos,Igor de Farias; Gonçalves,Sarah SantosWe report a case of invasive infection due to Saprochaete capitata in a patient with hematological malignancies after chemotherapy treatment and empiric antifungal therapy with caspofungin. Although severely immunocompromised the patient survived been treated with amphotericin B lipid complex associated with voriconazole.
Improving the solubility of the antichagasic drug benznidazole through formatio...
Sobrinho,José Lamartine Soares; Soares,Mônica Felts de La Roca; Labandeira,Juan Jose Torres; Alves,Lariza Darlene Santos; Rolim Neto,Pedro JoséThis study describes unpublished research on improving the solubility of benznidazole by the formation of an inclusion complex. The cyclodextrins selected were αCD, βCD, γCD, HPβCD, RMβCD and SBβCD. All complexes were obtained in solution, presenting 1:1 stoichiometry according to the phase solubility diagram. The highest association constants were obtained with RMβCD and SBβCD, being selected for attainment of...
Development of new dissolution test and HPLC-RP method for anti-parasitic ornid...
Soares,Mônica Felts de La Roca; Soares Sobrinho,José Lamartine; Grangeiro Júnior,Severino; Silva,Keyla Emanuelle Ramos da; Alves,Lariza Darlene SantosThis work aimed the development and validation of a new dissolution test for ornidazole coated tablets. The dissolution conditions were determined after testing Sink conditions, dissolution medium, apparatus, stirring speed, 24 h stability and medium filtration influence. The best conditions were paddle at a stirring speed of 75 rpm and 900 mL of 0.1 M HCl. A new HPLC quantification method was developed and val...
Variabilidade sazonal dos constituintes da própolis vermelha e bioatividade em ...
Nunes,Lívio César Cunha; Galindo,Alexandre Bezerra; Deus,Annalu da Silva Oliveira de; Rufino,Daniel Arcanjo; Randau,Karina PerrelliA própolis é uma substância resinosa coletada pelas abelhas de diversas partes das plantas. Sua composição depende da época, vegetação e local de coleta. Apresenta diversas atividades biológicas como antimicrobiana, antioxidante, antitumoral, dentre outras. Foi realizado estudo da variabilidade sazonal, nos meses de fevereiro, junho e outubro de 2006, dos constituintes voláteis da própolis vermelha de Pernambuc...
Development of dissolution method for benznidazole tablets
Lima,Ádley Antonini Neves de; Soares Sobrinho,José Lamartine; Silva,Jeckson Luiz da; Corrêa Júnior,Roberto Antônio CavadinhaThe aim of this work was the development of a dissolution method for benznidazole (BNZ) tablets. Three different types of dissolution media, two stirring speeds and apparatus 2 (paddle) were used. The accomplishment of the drug dissolution profiles was compared through the dissolution efficiency. The assay was performed by spectrophotometry at 324 nm. The better conditions were: sodium chloride\hydrochloride ac...
Purificação e caracterização da beta-lapachona e estudo de estabilidade dos cri...
Alves,Geisiane Maria Cavalcante; Rolim,Larissa Araújo; Rolim Neto,Pedro José; Leite,Ana Cristina Lima; Brondani,Dalci JoséThe beta-lapachone is a product obtained from the Ipê Roxo tree [Tabebuia avellandae], which has proved its excellent antineoplasic potential acting through a particular mechanism of apoptosis against various cancer types. This study aims at determining the identity card of beta-lapachone by means of physico-chemical and pharmaco-technical characterization. A purifying process has been performed, as well as the...
Desenvolvimento e validação de método analítico para determinação simultânea de...
Lavra,Zênia Maria Maciel; Rolim Neto,Pedro José; Silva,Rosali Maria Ferreira da; Medeiros,Flávia Patrícia Morais deAn analytical method has been developed and validated for the quantitation of lamivudine, zidovudine and nevirapine in the fixed-dose combination film-coated tablet by high performance liquid chromatography, in accordance with RE No. 899/2003, National Sanitary Surveillance Agency. It was based on an isocratic elution system with a potassium phosphate buffer pH 3.0: acetonitrile (60:40 v/v) mobile phase, C18, 2...
Desenvolvimento de método analítico por CLAE em comprimidos de Benznidazol para...
Silva,Ana Luiza Maurer da; Soares Sobrinho,José Lamartine; Rolim Neto,Pedro José; Silva,Rosali Maria Ferreira da; Medeiros,Flávia Patrícia Morais deThe analytical method of high performance liquid chromatography (HPLC) for the assay of benznidazole in tablets was developed and validated following the requirements of regulatory agencies. The method used as mobile phase acetonitrile:wather 1:1, a C18 column of 12.5 cm length x 4 mm id, 5 mm particles and lambda=316 nm. The statistical analysis of the results demonstrated that the method satisfies all paramet...