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Investigation of the genotoxicity of digested titanium dioxide nanomaterials in...
Vieira, Adriana; Vital, Nádia; Rolo, Dora; Roque, Rossana; Gonçalves, Lídia M.; Bettencourt, Ana; Silva, Maria João; Louro, HenriquetaFunding: This work was funded by national funds through the FCT - Foundation for Science and Technology, I.P., under the project PTDC/SAUPUB/29481/2017. Research co-funded by UIDB/00009/2020; UIDP/ 00009/2020 (Centre for Toxicogenomics and Human Health – ToxOmics, FCT- Foundation for Science and Technology). NV holds a FCT PhD Scholarship grant (2020.07168.BD). iMed.ULisboa (UIDB/04138/ 2020 and UIDP/04138/2020...
Adverse Outcome Pathways Associated with the Ingestion of Titanium Dioxide Nano...
Rolo, Dora; Assunção, Ricardo; Ventura, Célia; Alvito, Paula; Gonçalves, Lídia; Martins, Carla; Bettencourt, Ana; Jordan, Peter; Vital, NádiaFunding Information: This research was funded by the Portuguese Foundation for Science and Technology FCT/MCTES through national funds (PIDDAC), PTDC/SAU-PUB/29481/2017 and co-funded by UIDB/00009/2020 (Centre for Toxicogenomics and Human Health—ToxOmics (UIDP/00009/2020; UIDB/00009/2020), iMed.ULisboa (UIDB/04138/2020+UIDP/04138/2020), CESAM (UIDP/50017/2020+UIDB/50017/2020+LA/P/0094/2020), and BioISI (UID/MUL...
Cellular and Molecular Mechanisms of Toxicity of Ingested Titanium Dioxide Nano...
Vieira, Adriana; Gramacho, Ana; Rolo, Dora; Vital, Nádia; Silva, Maria João; Louro, HenriquetaFunding: This work was funded by national funds through the FCT - Foundation for Science and Technology, I.P., under the project INGESTnano- PTDC/ SAU-PUB/29481/2017. Research co-funded by European Union Seventh Framework Programme (FP7/ 2007e2013) under the project NANoREG (A common European approach to the regulatory testing of nanomaterials), grant agreement 310584 and by UIDB/00009/2020; UIDP/00009/2020 (Ce...
Analysis of the characteristics and cytotoxicity of titanium dioxide nanomateri...
Bettencourt, Ana; Gonçalves, Lídia M.; Gramacho, Ana C.; Vieira, Adriana; Rolo, Dora; Martins, Carla; Assunção, Ricardo; Alvito, PaulaSeveral metallic nanomaterials (NMs), such as titanium dioxide nanomaterials (TiO2), present beneficial properties with a broad range of innovative applications. The human population is exposed to TiO2, particularly by ingestion, due to its increasing use as a food additive and inclusion in dietary supplements and food packaging materials. Whether this oral exposure may lead to adverse local or systemic outcome...
LytA-based identification methods can misidentify Streptococcus pneumoniae
Simões, Alexandra S.; Tavares, Débora A.; Rolo, Dora; Ardanuy, Carmen; Goossens, Herman; Henriques-Normark, Birgitta; Linares, JosefinaDuring surveillance studies we detected, among over 1500 presumptive pneumococci, 11 isolates displaying conflicting or novel results when characterized by widely accepted phenotypic (optochin susceptibility and bile solubility) and genotypic (lytA-BsaAI-RFLP and MLST) identification methods. We aimed to determine the genetic basis for the unexpected results given by lytA-BsaAI-RFLP and investigate the accuracy...