9 documents found, page 1 of 1
Evaluation of bioenergetic and mitochondrial function in liver transplantation
Martins, Rui Miguel; Teodoro, João S.; Furtado, Emanuel; Rolo, Anabela Pinto; Palmeira, Carlos Marques; Tralhão, José GuilhermeBackground/Aims: We measured changes in mitochondrial function and bioenergetics that occur during ischemia/ reperfusion in fresh liver samples of patients undergoing liver transplantation. These variations correlated with markers of liver function and clinical outcome. Ischemia/reperfusion injury related to liver transplantation affects mitochondrial function and bioenergetics. Experimental studies were conduc...
Mild hypothermia during the reperfusion phase protects mitochondrial bioenerget...
Martins, Rui Miguel; Teodoro, João S.; Furtado, Emanuel; Oliveira, Rui Caetano; Tralhão, José Guilherme; Rolo, Anabela Pinto; Palmeira, Carlos MarquesThe organ preservation paradigm has changed following the development of new ways to preserve organs. The use of machine perfusion to preserve organs appears to have several advantages compared with conventional static cold storage. For liver transplants, the temperature control provided by machine perfusion improves organ preservation. In this experimental study, we measured the effects of different temperatur...
Recent insights into mitochondrial targeting strategies in liver transplantation
Martins, Rui Miguel; Teodoro, João Soeiro; Furtado, Emanuel; Rolo, Anabela Pinto; Palmeira, Carlos Marques; Tralhão, José GuilhermeIschemia/reperfusion (I/R) injury in liver transplantation can disrupt the normal activity of mitochondria in the hepatic parenchyma. This potential dysfunction of mitochondria after I/R injury could be responsible for the initial poor graft function or primary nonfunction observed after liver transplantation. Thus, determining the mechanisms that lead to human hepatic mitochondrial dysfunction might contribute...
Addition of Berberine to Preservation Solution in an Animal Model of Ex Vivo Li...
Martins, Rui Miguel; Rolo, Anabela Pinto; Teodoro, João Soeiro; Furtado, Emanuel; Oliveira, Rui Caetano; Tralhão, José GuilhermeLiver transplantation is a therapeutic regimen to treat patients with non-malignant end-stage liver diseases and malignant tumors of hepatic origin. The ischemia/reperfusion (I/R) injury in liver transplantation is associated with disruption of mitochondrial function in the hepatic parenchyma. Several studies have been conducted in animal models to identify pharmacological therapeutic strategies to minimize the...
Mitochondrial damage and apoptosis: Key features in BDE-153-induced hepatotoxicity
Pereira, Lilian Cristina [UNESP]; Cabral Miranda, Luiz Felipe; Franco-Bernardes, Mariana Furio; Tasso, Maria Julia; Duarte, Filipe ValenteMade available in DSpace on 2018-12-11T17:21:03Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-08-01; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Universidade de São Paulo; Brominated flame retardants are used in consumer goods to increase product resistance to fire and/or high temperatures. Polybrominated dip...
Exposure to BDE-153 induces autophagy in HepG2 cells
Pereira, Lilian Cristina [UNESP]; Duarte, Filipe Valente; Varela, Ana Teresa Inácio Ferreira; Rolo, Anabela Pinto; Palmeira, Carlos Manuel MarquesMade available in DSpace on 2018-12-11T17:23:27Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-08-01; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Autophagy is a pro-survival process that occurs under stressful “life-threatening” conditions. This pr...
PPARα Agonist WY-14643 Induces SIRT1 Activity in Rat Fatty Liver Ischemia-Reper...
Pantazi, Eirini; Folch-Puy, Emma; Bejaoui, Mohamed; Panisello, Arnau; Varela, Ana Teresa; Rolo, Anabela Pinto; Palmeira, Carlos M.Ischemia-reperfusion injury (IRI) remains a frequent complication in surgery, especially in case of steatotic livers that present decreased tolerance towards IRI. Apart from its major role in metabolism, activation of peroxisome proliferator-activated receptor α (PPARα) has been related with positive effects on IRI. In addition, the deacetylase enzyme sirtuin 1 (SIRT1) has recently emerged as a promising target...
Berberine reverts hepatic mitochondrial dysfunction in high-fat fed rats: A pos...
Teodoro, João Soeiro; Duarte, Filipe Valente; Gomes, Ana Patrícia; Varela, Ana Teresa; Peixoto, Francisco Manuel; Rolo, Anabela Pinto; Palmeira, C. M.Berberine is an isoquinoline alkaloid with anti-diabetic properties. Despite the central role of liver and thus hepaticmitochondria inwhole-bodymetabolism, berberine effects on hepaticmitochondrial function in an obesity model are still unknown. Here, we demonstrate that berberine treatment recovers mitochondrial efficiency when altered by a high-fat feeding.Mitochondria isolated from the liver of high-fat fed ...
Cholestasis and hepatic ischemia : bile acids therapy. cellular mechanisms with...
Rolo, Anabela PintoTese de doutoramento em Biologia (Biologia Celular) apresentada à Fac. de Ciências e Tecnologia de Coimbra