Made available in DSpace on 2019-10-06T16:08:34Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-12-01; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); β-thalassemia is a worldwide distributed monogenic red cell disorder, characterized by an absent or reduced beta globin chain synthesis. The unbalance of alpha-gamma chain and the presence of pathological free iron promote severe oxidative d...