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Genetic Manipulation Approaches to Enhance the Clinical Application of NK Cell-...
Maia, Andreia; Tarannum, Mubin; Romee, RizwanNatural killer (NK) cells are a subset of cytotoxic lymphocytes within the innate immune system. While they are naturally cytotoxic, genetic modifications can enhance their tumor-targeting capability, cytotoxicity, persistence, tumor infiltration, and prevent exhaustion. These improvements hold the potential to make NK-cell-based immunotherapies more effective in clinical applications. Currently, several viral ...
Building a Better Defense
Maia, Andreia; Tarannum, Mubin; Lérias, Joana R.; Piccinelli, Sara; BORREGO, LUIS MIGUEL; Maeurer, Markus; Romee, Rizwan; Castillo-Martin, MireiaFunding Information: This work was funded by the Fundação da Ciência e Tecnologia (FCT) with reference number SFRH/BD/144965/2019 and by the European Hematology Association (EHA) Research Mobility Grant 2023. Publisher Copyright: © 2024 by the authors.; Natural killer (NK) cells have gained attention as a promising adoptive cell therapy platform for their potential to improve cancer treatments. NK cells offer d...