20 documents found, page 1 of 2
Visceral leishmaniasis lethality in Brazil: an exploratory analysis of associat...
Donato,Lucas Edel; Freitas,Lúcia Rolim Santana de; Duarte,Elisabeth Carmen; Romero,Gustavo Adolfo SierraAbstract INTRODUCTION: It is believed that delays in diagnosis and treatment of Visceral Leishmaniasis (VL) contribute significantly to the burden of VL lethality in Brazil. METHODS: This study included several parts: a descriptive cross-sectional study of the individual characteristics of deaths from disease; a descriptive ecological study of the spatial distribution of deaths from disease; and an ecological a...
Efficacy and safety of amphotericin B deoxycholate versus N-methylglucamine ant...
Borges,Myrlena Mescouto; Pranchevicius,Maria Cristina da Silva; Noronha,Elza Ferreira; Romero,Gustavo Adolfo Sierra; Carranza-Tamayo,César OmarABSTRACT INTRODUCTION Despite their high toxicity, antimonials and amphotericin B deoxycholate are commonly used for treating visceral leishmaniasis (VL). Few studies showing conflictive data about their efficacy and adverse events in pediatric population are available. This study aimed to evaluate efficacy and safety of amphotericin B deoxycholate vs. that of N-methylglucamine antimoniate in treating pediatric...
Validation of the rapid test Carestart(tm) G6PD among malaria vivax-infected su...
Brito,Marcelo Augusto Mota; Peixoto,Henry Maia; Almeida,Anne Cristine Gomes de; Oliveira,Maria Regina Fernandes de; Romero,Gustavo Adolfo SierraAbstract: INTRODUCTION: In the Brazilian Amazon, malaria infections are primarily caused by Plasmodium vivax. The only drug that kills the hypnozoite form of P. vivax is primaquine, thereby preventing relapse. However, treating glucose-6-phosphate dehydrogenase (G6PD)-deficient individuals with primaquine can lead to severe hemolysis. G6PD deficiency (G6PDd) affects approximately 400 million people worldwide, m...
Are opossums a relevant factor associated with asymptomatic Leishmania infectio...
Carranza-Tamayo,César Omar; Werneck,Guilherme Loureiro; Romero,Gustavo Adolfo SierraAbstract A population survey was conducted to explore the prevalence and factors associated with Leishmania infection in the Fercal region of the Federal District. The Fercal region is a group of neighborhoods in Brasília in which the first cases of visceral leishmaniasis were described. Leishmania infection was established by a positive leishmanin test. Although other tests were performed in the study (an immu...
Polymerase chain reaction-based method for the identification of Leishmania (Vi...
Prestes,Suzane Ribeiro; Guerra,Jorge Augusto de Oliveira; Romero,Gustavo Adolfo Sierra; Magalhaes,Laylah Kelre Costa; Santana,Rosa Amelia GonçalvesABSTRACTINTRODUCTION: In the Americas, mucosal leishmaniasis is primarily associated with infection by Leishmania (Viannia) braziliensis. However, Leishmania (Viannia) guyanensis is another important cause of this disease in the Brazilian Amazon. In this study, we aimed at detecting Leishmaniadeoxyribonucleic acid (DNA) within paraffin-embedded fragments of mucosal tissues, and characterizing the infecting para...
Tegumentary leishmaniasis in the State of Amazonas: what have we learned and wh...
Guerra,Jorge Augusto de Oliveira; Maciel,Marcel Gonçalves; Guerra,Marcus Vinítius de Farias; Talhari,Anette Chursciack; Prestes,Suzane RibeiroThis study evaluated the occurrence of American tegumentary leishmaniasis (ATL) in the State of Amazonas, Brazil, in the last 30 years with emphasis on the last 10 years (2001 to 2010). The disease was predominantly observed in males (76.2%), in the 21- to 30-year-old age group (26.6%) and in extractive workers (43.7%); 3.3% of the cases were the mucosal form. The endemic channel shows the disease seasonality, ...
Poor response to azithromycin in cutaneous leishmaniasis leading to a premature...
Toledo Junior,Antonio; Daher,André Bastos; Amaral,Thaís Alves; Carvalho,Sílvio Fernando Guimarães; Romero,Gustavo Adolfo Sierra; Rabello,AnaIntroduction Parenteral antimony-based compounds are still the standard of care for cutaneous leishmaniasis (CL) treatment in many countries, despite their high toxicity. Previous studies showed that oral azithromycin could be an option for CL treatment. The aim of this study was to evaluate efficacy and safety of oral azithromycin (AZ) for CL treatment compared with injectable meglumine antimoniate (MA). Metho...
Clinical research monitoring: scenarios and challenges
Romero,Gustavo Adolfo SierraClinical research is essential for the development of new drugs, diagnostic tests and new devices. Clinical monitoring is implemented to improve the quality of research and attain high ethical and scientific standards. This review discusses the role of clinical monitors, taking into account the variety of scenarios in which medical research is developed, and highlights the challenges faced by research teams to ...
Congenitally transmitted visceral leishmaniasis: report of two brazilian human ...
Mescouto-Borges,Myrlena Regina Machado; Maués,Érika; Costa,Dorcas Lamounier; Pranchevicius,Maria Cristina da Silva; Romero,Gustavo Adolfo SierraVisceral leishmaniasis is a relevant public health problem worldwide. Most of the reported cases in Latin America are from Brazil. Herein we report two human cases of congenitally transmitted visceral leishmaniasis in two patients who developed symptoms during pregnancy. The diagnosis was made by visual examination of Leishmania parasites in bone marrow aspirates of the mothers and by detecting parasite kDNA in...
Mediastinitis and pericardial effusion in a patient with AIDS and disseminated ...
Cortez-Escalante,Juan José; Santos,Aline Marques dos; Garnica,Giovanna de Curcio; Sarmento,Ana Lucia; Castro,Cleudson Nery deWe report the case of a 36-year-old man who had acquired immune deficiency syndrome and developed suppurative mediastinitis extending over the left lung and anterior thoracic wall around the sternum, pericardial effusions, splenomegaly, and mesenteric and periaortic lymphadenomegaly due to Mycobacterium avium (genotype I). The organism was isolated from an axillary lymph node and the bone marrow. Mediastinitis ...