4 documents found, page 1 of 1
Mixed states in bipolar and major depressive disorders: systematic review and q...
Verdolini, N.; Hidalgo-Mazzei, D.; Murru, A.; Pacchiarotti, I.; Samalin, L.; Young, A. H.; Vieta, E.; Carvalho, A. F.Objective: This systematic review provided a critical synthesis and a comprehensive overview of guidelines on the treatment of mixed states. Method: The MEDLINE/PubMed and EMBASE databases were systematically searched from inception to March 21st, 2018. International guidelines covering the treatment of mixed episodes, manic/hypomanic, or depressive episodes with mixed features were considered for inclusion. A ...
Homocysteine as a peripheral biomarker in bipolar disorder : a meta-analysis
Salagre, E. S; Vizuete, A. F.; Leite, M.; Brownstein, D. J.; McGuinness, A.; Jacka, F.; Dodd, S.; Stubbs, B.; Köhler, C. A.; Vieta, E.; Carvalho, A. F.Background Bipolar disorder (BD) is a psychiatric disorder with an uncertain aetiology. Recently, special attention has been given to homocysteine (Hcy), as it has been suggested that alterations in 1-carbon metabolism might be implicated in diverse psychiatric disorders. However, there is uncertainty regarding possible alterations in peripheral Hcy levels in BD. Methods This study comprises a meta-analysis com...
The catechol-O- methyltransferase (COMT) Val158Met genotype modulates working m...
Miskowiak, K. W.; Kjærstad, H. L.; Støttrup, M. M.; Svendsen, A. M.; Demant, K. M.; Hoeffding, L. K.; Werge, T. M.; Burdick, K. E.; Domschke, K.Objectives: Cognitive dysfunction affects a substantial proportion of patients with bipolar disorder (BD), and genetic-imaging paradigms may aid in the elucidation of mechanisms implicated in this symptomatic domain. The Val allele of the functional Val158Met polymorphism of the catechol-O- methyltransferase (COMT) gene is associated with reduced prefrontal cortex dopamine and exaggerated working memory-related...
Neuropsychological testing of cognitive impairment in euthymic bipolar disorder...
Bourne, C.; Aydemir, Ö.; Balanzá-Martínez, V.; Bora, E.; Brissos, S.; Cavanagh, J. T. O.; Clark, L.; Cubukcuoglu, Z.; Dias, V. V.; Dittmann, S.Objective: An association between bipolar disorder and cognitive impairment has repeatedly been described, even for euthymic patients. Findings are inconsistent both across primary studies and previous meta-analyses. This study reanalysed 31 primary data sets as a single large sample (N = 2876) to provide a more definitive view. Method: Individual patient and control data were obtained from original authors for...