5 documents found, page 1 of 1
Comparative Outcomes of Extracorporeal Membrane Oxygenation for COVID-19 Delive...
Schmidt, Matthieu; Hajage, David; Landoll, Micha; Pequignot, Benjamin; Langouet, Elise; Amalric, Matthieu; Mekontso-Dessap, Armand; Chiscano-Camon, LuisBackground: To inform future research and practice, we aimed to investigate the outcomes of patients who received extracorporeal membrane oxygenation (ECMO) for acute respiratory distress syndrome (ARDS) due to different variants of SARS-CoV-2. Methods: This retrospective study included consecutive adult patients with laboratory-confirmed SARS-CoV-2 infection who received ECMO for ARDS in 21 experienced ECMO ce...
Primary amyloidosis associated with kappa light chain myeloma.
Martins, Raquel G; Roncon-Albuquerque, Roberto; Cabral, Raquel; Frazão, João; Von Hafe, PedroThe clinical spectrum of plasma cell dyscrasias includes primary amyloidosis and multiple myeloma. These two entities are present at the time of diagnosis in 10 percent of cases.A 72 years old female was admitted to our Institution with oligoanuric renal failure. Renal ultrasonography revealed normal kidney dimensions, with a slight decrease in the normal parenchyma-sinus differentiation. The complementary stud...
Time course and mechanisms of left ventricular systolic and diastolic dysfuncti...
Correia-Pinto, Jorge; Henriques-Coelho, Tiago; Roncon-Albuquerque, Roberto; Lourenço, André P.; Rocha, Gustavo Filipe Melo AlvesAlthough pulmonary hypertension (PH) selectively overloads the right ventricle (RV), neuroendocrine activation and intrinsic myocardial dysfunction have been described in the left ventricle (LV). In order to establish the timing of LV dysfunction development in PH and to clarify underlying molecular changes, Wistar rats were studied 4 and 6 weeks after subcutaneous injection of monocrotaline (MCT) 60 mg/kg (MCT...
Thymulin inhibits monocrotaline-induced pulmonary hypertension modulating inter...
Henriques-Coelho, Tiago; Oliveira, Sílvia Marta; Moura, Rute S.; Roncon-Albuquerque, Roberto; Neves, Ana Luísa; Santos, MárioThe pathogenesis of pulmonary hypertension (PH) includes an inflammatory response. Thymulin, a zinc-dependent thymic hormone, has important immunobiological effects by inhibiting various proinflammatory cytokines and chemokines. We investigated morphological and hemodynamic effects of thymulin administration in a rat model of monocrotaline (MCT)-induced PH, as well as the pattern of proinflammatory cytokine gen...
Ghrelin expression in human and rat fetal lungs and the effect of ghrelin admin...
Santos, Marta; Bastos, Pedro; Gonzaga, Silvia; Roriz, José-Mário; Baptista, Maria J.; Silva, Cristina Isabel Nogueira; Rocha, Gustavo Filipe Melo AlvesGhrelin is a strong physiologic growth hormone secretagogue that exhibits endocrine and non-endocrine actions. In this study, ghrelin expression in humans and rats was evaluated throughout development of normal and hypoplastic lungs associated with congenital diaphragmatic hernia (CDH). Additionally, the effect of antenatal treatment with ghrelin in the nitrofen-induced CDH rat model was tested. In normal lungs...