3 documents found, page 1 of 1
In major affective disorders, early life trauma predict increased nitro-oxidati...
Moraes, Juliana Brum; Maes, Michael; Roomruangwong, Chutima; Bonifacio, Kamila Landucci; Barbosa, Decio Sabbatini; Vargas, Heber OdebrechtEarly life trauma (ELT) may increase the risk towards bipolar diso rder (BD) and major depression (MDD), disorders associated with activated neuro-oxidative and neuro-nitrosative stress (O&NS) p athways. It has remained elusive whether ELTs are associated with O&NS and which ELTs are associated with disti nct affective disorder phenotypes. This case-control study examined patients with BD ( n = 68) and MDD ( n ...
IgM-mediated autoimmune responses to oxidative specific epitopes, but not nitro...
Roomruangwong, Chutima; Kanchanatawan, Buranee; Sirivichayakul, Sunee; Anderson, George; Carvalho, André F.; Duleu, Sebastien; Geffard, MichelImmunoglubulin (Ig)M responses directed to oxida- tive specific epitopes (OSEs) and nitric oxide (NO)-adducts are significantly associated with major depression and physio- somatic symptoms. End of term serum IgM responses to OSEs and NO-adducts were assayed in pregnant women with ( n =24) and without prenatal depression ( n = 25) as well as in 24 non- pregnant women. Associations of IgM/IgA responses to Gram- ...
Activated neuro-oxidative and neuro-nitrosative pathways at the end of term are...
Roomruangwong, Chutima; Barbosa, Decio Sabbatini; Matsumoto, Andressa Keiko; Nogueira, André de Souza; Kanchanatawan, Buranee; Sirivichayakul, SuneeObjectives: To examine oxidative & nitrosative stress (O & NS) biomarkers at the end of term in relation to perinatal affective symptoms, neuro-immune biomarkers and pregnancy-related outcome variables. Methods: We measured plasma advanced oxidation protein products (AOPP), nitric oxide metabolites (NOx), total radical trapping antioxidant parameter (TRAP), -sulfhydryl (-SH), peroxides (LOOH) and paraoxonase (P...