3 documents found, page 1 of 1
Release of insulin from PLGA-alginate dressing stimulates regenerative healing ...
Dhall, S.; Silva, João P.; Liu, Y.; Hrynyk, M.; Garcia, M.; Chan, A.; Lyubovitsky, J.; Neufeld, R.; Martins-Green, M.Burn wound healing involves a complex set of overlapping processes in an environment conducive to ischemia, inflammation, and infection costing $7.5 billion/year in the US alone, in addition to the morbidity and mortality that occur when the burns are extensive. We previously showed that insulin, when topically applied to skin excision wounds, accelerates re-epithelialization, and stimulates angiogenesis. More ...
Improved burn wound healing by the antimicrobial peptide LLKKK18 released from ...
Silva, João P.; Dhall, S.; Garcia, M; Costa, C.; Chan, A.; Gama, F. M.; Martins-Green, M.Antimicrobial peptides (AMPs) are good candidates to treat burn wounds, a major cause of morbidity, impaired life quality and resources consumption in developed countries. We took advantage of a commercially available hydrogel, Carbopol, a vehicle for topical administration that maintains a moist environment within the wound site. We hypothesized that the incorporation of LLKKK18 conjugated to dextrin would imp...
Assessment of burn wound tissue in situ by multiphoton microscopy employing flu...
Silva, João P.; Dhall, S.; Martins-Green, M.; Lyubovitsky, J. G.Current assessment of burn wound depth and progression of healing for proper choice of treatment is based on time-consuming and invasive techniques that may interfere with the healing process. One way to overcome these problems is to use noninvasive techniques. We use multiphoton microscopy (MPM) that employs fluorescence and second harmonic generation (SHG) contrasts to noninvasively follow the burn healing pr...