23 documents found, page 1 of 3

An Overview of Monkeypox Virus Detection in Different Clinical Samples and Anal...

Mpox is a zoonotic disease caused by the Monkeypox virus (MPXV), and since May 2022, tens of thousands of cases have been reported in non-endemic countries. We aimed to evaluate the suitability of different sample types for mpox diagnostic and assess the temporal dynamics of viral load. We evaluated 1914 samples from 953 laboratory-confirmed cases. The positivity rate was higher for lesion (91.3%) and rectal sw...

Unveiling a Listeria monocytogenes Outbreak in a Rabbit Farm: Clinical Manifest...

Listeria monocytogenes poses a threat to both human and animal health. This work describes an L. monocytogenes outbreak in a Portuguese rabbit farm, detailing the isolates’ clinical manifestations, necropsy findings, and phenotypic and genomic profiles. Clinical signs, exclusively observed in does, included lethargy and reproductive signs. Post-mortem examination of does revealed splenomegaly, hepatomegaly with...

Ongoing outbreak of hepatitis A associated with sexual transmission among men w...

An outbreak of hepatitis A is ongoing in Portugal, with 71 confirmed cases from 7 October 2023 to 24 April 2024. Most cases are male, aged 18-44 years, with many identifying as men who have sex with men (MSM) and reported as suspected sexual transmission. Phylogenetic analysis identified the subgenotype IA, VRD 521-2016 strain, last observed in an MSM-associated multi-country outbreak in 2016 to 2018. We wish t...

Uma Apresentação Atípica e Não-Cardíaca de Cardiomiopatia Hipertrófica

Estudo da imunidade adquirida pela vacinação contra a COVID-19 em profissionais...

O presente relatório de execução, elaborado pelo Departamento de Epidemiologia, o Departamento de Doenças Infeciosas e os Serviços de Saúde Ocupacional do INSA, apresenta os resultados de implementação dos 12 meses do estudo, desenvolvido para estimar a efetividade da vacina contra a COVID-19 em profissionais de saúde do Instituto Nacional de Saúde Doutor Ricardo Jorge (INSA). Neste relatório é apresentada info...

Investigating the impact of COVID-19 vaccines on the red blood cell immune func...

The role of red blood cells (RBC) in the immune system is increasingly recognized. However, RBC-derived molecules with an immunomodulatory role in health and disease, as well as in vaccine immunogenicity are still poorly investigated. Taking as a model the emergent COVID-19 vaccines, we aimed to investigate whether vaccines induce proteome and/or metabolome changes in RBCs able to affect T-cell immune activity,...

Portuguese National Serological Survey to Coronavirus Disease 19 - ISNCOVID-19

The objective of this seroepidemiological survey was to estimate seroprevalence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) specific antibodies (IgM and/or IgG) in Portugal in May-July 2020. The seroprevalence of SARS-Cov-2 infection (positive for IgM and/or IgG) was 2.9% (CI95: 2.0 - 4.2%). Our results support extend limited extent of infection by SARS-CoV-2 in Portugal due to early lockdow...

RBF-FD meshless optimization using direct search (GLODS) in the analysis of com...

An optimization technique, Global and Local Optimization using Direct Search (GLODS) is used to optimize stencil size and shape parameter of the multiquadric function used in the Radial Basis Function-Finite Difference (RBF-FD) meshless numerical method. The mechanical problem to be solved by the meshless method is a composite plate in bending, under sinusoidal load. Results show GLODS is capable of finding val...

Genital Herpes in a STD outpatient clinic in Lisbon

Introduction: Genital Herpes is the major cause of genito-ulcerative disease affecting a considerable number of individuals worldwide and is a chronic, life-long viral infection caused by both HSV1 or HSV2. Most cases of recurrent genital herpes are caused by HSV2, being the leading cause of genital ulcer disease in developing countries, but the proportion of anogenital herpetic infections attributed to HSV1 ar...

Molecular studies on HSV: replication rate, infection capacity and progeny

Introduction: In the last years genital herpes has emerged as one of the most prevalent sexually transmitted infections. Herpes simplex virus (HSV) is the most common cause of genital ulcer disease, with infections caused by both sub-types HSV-1 and HSV-2. A better understanding of the virus replication cycle is relevant to the pathogenesis of human diseases and is essential for the development of antiviral che...