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ArtinM: purification and evaluation of biological activities

The lectin-specific activity of Toxoplasma gondii microneme proteins 1 and 4 bi...

Receptor heterodimerization and co-receptor engagement in TLR2 activation induc...

Nasal vaccination with attenuated Salmonella expressing VapA: TLR2 activation i...

Virulent strains of Rhodococcus equi have a large plasmid of 80–90 kb, which encodes several virulence-associated proteins (Vap), including VapA, a lipoprotein highly associated with disease. We have previously demonstrated that oral immunisation with attenuated Salmonella enterica Typhimurium strain expressing the antigen VapA (STM VapA+) induces specific and long-term humoral and cellular immunity against R. ...

Impact of paracoccin gene silencing on Paracoccidioides brasiliensis virulence

Paracoccin distribution supports its role in Paracoccidioides brasiliensis grow...

CD14 is critical for TLR2-mediated M1 macrophage activation triggered by N-glyc...

Paracoccin distribution supports its role in Paracoccidioides brasiliensis grow...

Paracoccidioides brasiliensis yeast was reported to express paracoccin, a GlcNAc-binding protein that displays N-acetyl-β-d-glucosaminidase (NAGase) activity. Highly specific anti-paracoccin antibodies have been previously used to examine the localization of paracoccin in yeast and inhibit its growth in vitro. In the present study, anti-paracoccin antibodies were used to characterize, by scanning confocal micro...

Impact of paracoccin gene silencing on Paracoccidioides brasiliensis Virulence

Among the endemic deep mycoses in Latin America, paracoccidioidomycosis (PCM), caused by thermodimorphic fungi of the Paracoccidioides genus, is a major cause of morbidity. Disease development and its manifestations are associated with both host and fungal factors. Concerning the latter, several recent studies have employed the methodology of gene modulation in P. brasiliensis using antisense RNA (AsRNA) and Ag...

Yeast expressed ArtinM shares structure, carbohydrate recognition, and biologic...