11 documents found, page 1 of 2
Assessing the in vitro toxicity of airborne (nano)particles to the human respir...
Bessa, Maria João; Brandão, Fátima; Rosário, Fernanda; Moreira, Luciana; Reis, Ana Teresa; Valdiglesias, Vanessa; Laffon, Blanca; Fraga, SóniaSeveral studies have been conducted to address the potential adverse health risks attributed to exposure to nanoscale materials. While in vivo studies are fundamental for identifying the relation-ship between dose and occurrence of adverse effects, in vitro model systems provide important information regarding the mechanism(s) of action at the molecular level. With a special focus on exposure to inhaled (nano)p...
In Vitro Hepatotoxic and Neurotoxic Effects of Titanium and Cerium Dioxide Nano...
Rosário, Fernanda; Costa, Carla; Lopes, Cláudia B.; Estrada, Ana C.; Tavares, Daniela S.; Pereira, Eduarda; Teixeira, João Paulo; Reis, Ana TeresaConsidering the increasing emergence of new contaminants, such as nanomaterials, mixing with legacy contaminants, including metal(loid)s, it becomes imperative to understand the toxic profile resulting from these interactions. This work aimed at assessing and comparing the individual and combined hepatotoxic and neurotoxic potential of titanium dioxide nanoparticles (TiO2NPs 0.75-75 mg/L), cerium oxide nanopart...
In Vitro Cyto- and Genotoxicity Assessment of Antibacterial Paints with Triclos...
Querido, Micaela; Rosário, Fernanda; Bessa, Maria; Mendes, Francisca; Teixeira, José; Teixeira, João; Pereira, CristianaSurfaces with antimicrobial properties are gaining notoriety as an efficient method to avoid surface contamination. Self-disinfecting paints are a promising strategy towards cleaner indoor environments by preventing the colonization of walls with microorganisms. However, its widespread use needs an appropriate toxicological safety evaluation due to the potential for biological disturbance associated to its bioc...
Co-exposure with CeO2NPs results in an antagonistic effect on the cytotoxicity ...
Rosário, Fernanda; Vilaça, Cláudia; Costa, Carla; Lopes, Cláudia B.; Estrada, Ana C.; Tavares, Daniela S.; Teixeira, João Paulo; Reis, Ana TeresaObjective: Assess the CYTOTOXIC and GENOTOXIC POTENTIAL resulting from titanium dioxide nanoparticles (TiO2NP) and cerium oxide nanoparticles (CeO2NP) co-exposure in human lung epithelial cell line A549.
Quaternary mixtures of TiO2NP, CeO2NP, arsenic, and mercury potentiate A549, He...
Rosário, Fernanda; Costa, Carla; Teixeira, João; Reis, Ana TeresaIntroduction: Nanoparticles (NP) released to the environment interact with pre-existing contaminants, potentially leading to cytotoxicity and raising concerns regarding human safety to co- exposure to multiple chemicals. This work assesses and compares viability of A549, HepG2 and SH-SY5Y cells after short (24h; WST-1 assay) and long-term (7 days; clonogenic assay) exposure to single and quaternary mixtures of:...
Genotoxicity of TiO2 Nanoparticles in Four Different Human Cell Lines (A549, HE...
Brandão, Fátima; Fernández-Bertólez, Natalia; Rosário, Fernanda; Bessa, Maria João; Fraga, Sónia; Pásaro, Eduardo; Teixeira, João Paulo; Laffon, BlancaTitanium dioxide nanoparticles (TiO2 NPs) have a wide variety of applications in many consumer products, including as food additives, increasing the concern about the possible hazards that TiO2 NPs may pose to human health. Although most previous studies have focused on the respiratory system, ingestion must also be considered as an important exposure route. Furthermore, after inhalation or ingestion, TiO2 NPs ...
Assessment of genotoxic effects of titanium dioxide nanoparticles on different ...
Fernández-Bertólez, Natalia; Brandao, Fátima; Rosário, Fernanda; Bessa, Maria João; Fraga, Sónia; Pásaro, Eduardo; Teixeira, Joao Paulo; Costa, CarlaThe main objective of the present work was to assess the cellular uptake and potential genotoxicity (micronuclei induction) of TiO2 NPs on four diverse human cell lines.
Cytotoxic effects of single and binary mixtures of metal oxide nanoparticles an...
Rosário, Fernanda; Bessa, Maria João; Brandão, Fátima; Costa, Carla; Lopes, Cláudia B.; Estrada, Ana Cristina; Tavares, Daniela S.; Teixeira, João PauloBackground, Motivation and Objective: The need to assess the toxicity resulting from exposure to mixtures of chemicals has been recognized by the WHO and EU, as humans are simultaneously exposed to an array of natural and anthropogenic contaminants. Of particular interest are the potential combined effects resulting from interaction of nanoparticles (NPs) and metals. While the first are the current driving forc...
Unravelling the Potential Cytotoxic Effects of Metal Oxide Nanoparticles and Me...
Rosário, Fernanda; Bessa, Maria João; Brandão, Fátima; Costa, Carla; Lopes, Cláudia B.; Estrada, Ana C.; Tavares, Daniela S.; Teixeira, João PauloHumans are typically exposed to environmental contaminants' mixtures that result in different toxicity than exposure to the individual counterparts. Yet, the toxicology of chemical mixtures has been overlooked. This work aims at assessing and comparing viability and cell cycle of A549 cells after exposure to single and binary mixtures of: titanium dioxide nanoparticles (TiO2NP) 0.75-75 mg/L; cerium oxide nanopa...
A first insight into the genotoxicity induced on A549 human cell line by titani...
Vilaça, Cláudia; Rosário, Fernanda; Bessa, Maria João; Ribeiro, César; Costa, Carla; Teixeira, João Paulo; Reis, Ana TeresaObjectives: Nanogenotoxicity studies traditionally consider exposure to a single NP. However, potential genotoxicity resulting from exposure to mixtures of NP and other contaminants cannot be neglected; This work will constitute the first insight into the DNA damage induced on A549 cells by exposure to binary mixtures of titanium (TiO2) and cerium (CeO2) dioxide, and highly toxic metals arsenic (As) and mercury...