2 documents found, page 1 of 1
Analysis of shared heritability in common disorders of the brain
Anttila, Verneri; Bulik-Sullivan, Brendan; Finucane, Hilary K.; Walters, Raymond K.; Bras, Jose; Duncan, Laramie; Escott-Price, ValentinaDisorders of the brain can exhibit considerable epidemiological comorbidity and often share symptoms, provoking debate about their etiologic overlap. We quantified the genetic sharing of 25 brain disorders from genome-wide association studies of 265,218 patients and 784,643 control participants and assessed their relationship to 17 phenotypes from 1,191,588 individuals. Psychiatric disorders share common varian...
Single-Objective Front Optimization: Application to RF Circuit Design
Pires, E. J. Solteiro; Mendes, Luís; Oliveira, P. B. de Moura; Tenreiro Machado, J. A.; Ferreira, N. M. Fonseca; Vaz, João; Rosário, MariaThis paper proposes a new algorithm which promotes well distributed non-dominated fronts in the parameters space when a single- objective function is optimized. This algorithm is based on ǫ-dominance concept and maxmin sorting scheme. Besides that, the paper also presents the results of the algorithm when it is used in the automated synthesis of optimum performance CMOS radiofrequency and microwave binary-weigh...