2 documents found, page 1 of 1
Medicinal Plants as a Source of Antiplasmodial Compounds
Ramalhete, Cátia; Lopes, D; Mulhovo, S; Rosário, V; Ferreira, MJUInfectious diseases caused by bacteria, fungi, viruses and parasites are a major threat to public health, despite great progress in therapy. The impact of infectious diseases is especially important in developing countries, where drugs are limited and the emergence of widespread drug resistance is a reality.1 Malaria is a major parasitic disease in the tropical and subtropical regions of the world. It is respon...
Inhibition of P-glycoprotein activity by cucurbitane-type triterpenes and their...
Ramalhete, Cátia; Duarte, N; Capucha, V; Molnár, J; Mulhovo, S; Rosário, V; Ferreira, MJUThe overexpression of P- glycoprotein (P-gp) is one of the mechanisms of multidrug resistance (MDR), responsible for the failure of cancer treatment. One strategy to restore the effectiveness of the anti-cancer drugs is to co-administer compounds that are not toxic themselves, but inhibit these efflux pumps. These compounds have been called MDR inhibitors, MDR modulators, MDR reversal agents or chemosensitizers...