4 documents found, page 1 of 1
Can sexual transmission support the enzootic cycle of Trypanosoma cruzi?
Rios, Adriano; Ribeiro, Marcelle; Sousa, Alessandro; Pimentel, Fernando; Hagström, Luciana; Andrade, Rafael; Alves, Rozeneide M.; Rosa, Ana de CássiaBACKGROUND Trypanosoma cruzi circulates in sylvatic habitats, mainly through blood-feeding triatomines, although other routes also contribute to its dispersion. Sexual transmission of T. cruzi is an understudied topic, especially among wild mammals. Because of the difficulties inherent to field work, experimentally infected mice are frequently used to evaluate the transmission of T. cruzi. OBJECTIVE This study ...
Trypanosoma cruzi in the chicken model : Chagas-like heart disease in the absen...
Teixeira, Antonio Raimundo Lima Cruz; Gomes, Clever; Nitz, Nadjar; Sousa, Alessandro O.; Alves, Rozeneide M.; Guimaro, Maria C.; Cordeiro, CiroBackground: The administration of anti-trypanosome nitroderivatives curtails Trypanosoma cruzi infection in Chagas disease patients, but does not prevent destructive lesions in the heart. This observation suggests that an effective treatment for the disease requires understanding its pathogenesis. Methodology/Principal Findings: To understand the origin of clinical manifestations of the heart disease we used a ...
Environment, interactions between Trypanosoma cruzi and its host, and health
Teixeira, Antonio Raimundo Lima Cruz; Gomes, Clever; Lozzi, Silene P.; Hecht, Mariana M.; Rosa, Ana de Cássia; Monteiro, Pedro S.Uma rede epidemiológica envolvendo o Trypanosoma cruzi foi discutida nos níveis ambientais e de interações moleculares nos hospedeiros que habitam em 19 diferentes ecossistemas. O protozoário tem uma enorme plasticidade controlada geneticamente que confere sua adaptação a cerca de quarenta espécies de triatomíneos e mais de mil espécies de mamíferos. Essas infecções estão profundamente embutidas em inúmeros ecó...
Inheritance of DNA transferred from American Trypanosomes to human hosts
Hecht, Mariana M.; Nitz, Nadjar; Araujo, Perla F.; Sousa, Alessandro O.; Rosa, Ana de Cássia; Gomes, Dawidson A.; Leonardecz, EduardoInterspecies DNA transfer is a major biological process leading to the accumulation of mutations inherited by sexual reproduction among eukaryotes. Lateral DNA transfer events and their inheritance has been challenging to document. In this study we modified a thermal asymmetric interlaced PCR by using additional targeted primers, along with Southern blots, fluorescence techniques, and bioinformatics, to identif...