10 documents found, page 1 of 1

Effects of oral supplementation of black-eyed-bean (Vigna unguiculata) in ICR m...

Grain legumes are a main source of nutrients in some countries. Black-eyed-bean (BEB) (Vigna unguiculata), a member of theFabaceae family, is a grain legume consumed worldwide due to its high content of bioactive molecules that promote human health. This study aimed to evaluate the effects of 70% BEB flour (BEBF) (w/w) supplementation in ICR healthy mice for 13 weeks. Body and organs weights, as well as food an...

Characterizing the molecular and physiological changes associated with colorect...

Characterizing the molecular and physiological changes associated with colorectal cancer in wistar rats

An integrative approach to characterize the early phases of dimethylhydrazine-i...

This study aimed to characterize an animal model of colorectal cancer (CRC) in the early stages of disease development. Twenty-nine male Wistar rats were divided into two control groups (CTRL1 and CTRL2), receiving EDTA–saline injections and two induced groups (CRC1 and CRC2), receiving 1,2-dimethylhydrazine (DMH) injections for seven consecutive weeks. CRC1 and CTRL1 were euthanized at the 11th week, while CRC...

The red seaweed Grateloupia turuturu prevents epidermal dysplasia in HPV16-tran...

Abstract: The role of dietary profiles in promoting or reducing the risk of multiple types of cancer is increasingly clear, driving the search for balanced foods and nutraceuticals. The red seaweed Grateloupia turuturu has been used as human food showing a balanced nutritional profile. This study aims to test in vivo chemopreventive effects of G. turuturu against cutaneous pre-malignant lesions in transgenic mi...

The influence of Castanea sativa Mill. flower extract on hormonally and chemica...

Prostate cancer (PCa) is one of the most common cancers in men, with a huge impact on their health. The use of Castanea sativa Mill. flowers (CFs) in beverages has been reported, through ancestral claims, as having health benefits. In vitro research has evidenced the properties of CFs, such as antitumor and anti- oxidant activities. This study aimed to evaluate the effects of CF extract in an animal model of PC...

Dietary supplementation with chestnut (Castanea sativa) reduces abdominal adipo...

The production of chestnut (Castanea sativa Miller) is mostly concentrated in Europe. Chestnut is recognized by its high content of antioxidants and phytosterols. This work aimed to evaluate the effects of dietary chestnut consumption over physiological variables of FVB/n mice. Eighteen FVB/n male 7-month-old mice were randomly divided into three experimental groups (n = 6): 1 (control group) fed a standard die...

The mechanism of hydrolysis of aryl ether derivatives of 3-hydroxymethyltriazenes

1-Aryl-3-aryloxymethyl-3-methyltriazenes hydrolyse to the corresponding anilines and phenols by specific-acid-catalysed, general-acid-catalysed and pH-independent mechanisms. All compounds studied exhibit specific- and general acid catalysis, though for 5a general acid catalysis was not observed below a pH of approximately 4, while for compounds 5e,f, such catalysis was absent above a pH of approximately 5. The...

Communication-based on topology preservation of chaotic dynamics

Triazene drug metabolites. Part 17

A series of 3-acyloxymethyloxycarbonyl-1-aryl-3-methyltriazenes 5 was synthesised by the sequential reaction of 1-aryl-3-methyltriazenes with (i) chloromethyl chloroformate, (ii) NaI in dry acetone, and (iii) either the silver carboxylate or the carboxylic acids in the presence of silver carbonate. The hydrolysis of these compounds was studied in pH 7.7 isotonic phosphate buffer and in human plasma. Triazene ac...

Alergia Alimentar em Crianças numa Consulta de Imunoalergologia

Estima-se que a prevalência de alergia alimentar nos países Ocidentais seja de cerca de 2 % na população geral e até 8% em crianças, não existindo dados concretos no que diz respeito a Portugal. Objectivos: Avaliar a prevalência de alergia alimentar e identificar os alergenos alimentares principais numa população de crianças observadas na Consulta de Imunoalergologia do Hospital de Dona Estefânia num período de...