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Comparative Studies on the Photoreactivity, Efficacy, and Safety of Depigmentin...

Mota, Sandra; Rosa, Gonçalo P.; Barreto, Maria Carmo; Garrido, Jorge; Sousa, Emília; Cruz, Maria T.; Almeida, Isabel F.; Quintas, Clara; Garrido, Jorge

Depigmenting products are increasingly used to counteract skin hyperpigmentation and related psychosocial issues. This study aimed to compare different depigmenting agents—4-butylresorcinol; bakuchiol; tranexamic acid; ascorbyl glucoside; α-arbutin; and ascorbic acid—for photoreactivity; tyrosinase inhibition; and safety. Photoreactivity was assessed using the Reactive Oxygen Species assay. In vitro tyrosinase ...


New Phytol Derivatives with Increased Cosmeceutical Potential

Rosa, Gonçalo P.; Seca, Ana M. L.; Pinto, Diana. C. G. A.; Barreto, Maria Do Carmo

Natural compounds are widely incorporated into cosmetic products for many purposes. Diterpenes often function as fragrances, enhancing the sensory experience of these formulations. However, current trends in cosmetic science aim to develop multifunctional products, where compounds traditionally used for texture or fragrance also possess biological activities that contribute to the product’s efficacy. In this co...


Comparative studies on the photoreactivity, efficacy, and safety of depigmentin...

Mota, Sandra; Rosa, Gonçalo P.; Barreto, Maria Carmo; Garrido, Jorge; Sousa, Emília; Cruz, Maria T.; Almeida, Isabel F.; Quintas, Clara

Depigmenting products are increasingly used to counteract skin hyperpigmentation and related psychosocial issues. This study aimed to compare different depigmenting agents—4-butylresorcinol; bakuchiol; tranexamic acid; ascorbyl glucoside; α-arbutin; and ascorbic acid—for photoreactivity; tyrosinase inhibition; and safety. Photoreactivity was assessed using the Reactive Oxygen Species assay. In vitro tyrosinase ...


Comparative Studies on the Photoreactivity, Efficacy, and Safety of Depigmentin...

Mota, Sandra; Rosa, Gonçalo P.; Barreto, Maria Carmo; Garrido, Jorge; Sousa, Emília; Cruz, Maria Teresa; Almeida, Isabel F.; Quintas, Clara

Depigmenting products are increasingly used to counteract skin hyperpigmentation and related psychosocial issues. This study aimed to compare different depigmenting agents—4-butylresorcinol; bakuchiol; tranexamic acid; ascorbyl glucoside; α-arbutin; and ascorbic acid—for photoreactivity; tyrosinase inhibition; and safety. Photoreactivity was assessed using the Reactive Oxygen Species assay. In vitro tyrosinase ...


Chemical Composition and Phytopharmaceuticals : An Overview of the Caulerpa and...

Rosa, Gonçalo P.; Barreto, Maria do Carmo; Seca, Ana M. L.; Pinto, Diana C. G. A.

In recent years, macroalgae attracted increasing attention from many industries of diverse branches such as plastics, cosmetics, pharmaceuticals, and food. This interest is due to the diverse chemical composition existing within the various macroalgae classes, which offer the possibility of finding a wide array of primary and secondary metabolites with exciting properties and great potential for pharmacological...


Cosmeceutical Potential of the Green Macroalga Caulerpa Prolifera

Rosa, Gonçalo P.; Seca, Ana M. L.; Barreto, Maria do Carmo; Pinto, Diana C. G. A.

The present cosmeceutical industry has been gradually shifting its interest from products based on synthetic compounds to macroalgae-based products due to their interesting antiaging properties but also to their lower cytotoxicity and allergens content. Molecules isolated from macroalgae already showed potential as either active cosmetic ingredients or key elements for the consistency of the cosmetic formulatio...


Valorization of Macaronesia Beach-Cast Seaweeds : Secondary Metabolites and Ant...

Seca, Ana M. L.; Faustino, Luís M. M.; Viveiros, Mariana Moniz; Rosa, Gonçalo P.; Barreto, Maria do Carmo

Beach-cast seaweeds are a seasonal phenomenon consisting of the accumulation of large tons of algae on beaches, which is unpleasant for beach users and affects the tourism industry, mainly because tourists often interpret stranded natural litter as lowering beach quality, especially if the material starts to decompose. These beach casts are always variable mixtures of different species of seagrass and seaweeds....


GC- and UHPLC-MS Profiles as a Tool to Valorize the Red Alga Asparagopsis armata

Pinto, Diana C. G. A.; Lesenfants, Marie L.; Rosa, Gonçalo P.; Barreto, Maria do Carmo; Silva, Artur M. S.; Seca, Ana M. L.

Asparagopsis armata Harvey is a red alga native from the southern hemisphere and then introduced in the Mediterranean Sea and the Atlantic Ocean, including the Azores Archipelago, where it is considered an invasive alga. Some studies show that the extracts exhibit antimicrobial and antifouling activities, and it is incorporated in some commercialized cosmetic products. (e.g., Ysaline®). However, knowledge of th...


Bio-Guided Optimization of Cystoseira abies-marina Cosmeceuticals Extraction by...

Rosa, Gonçalo P.; Peixoto, Andreia F.; Barreto, Maria do Carmo; Seca, Ana M. L.; Pinto, Diana C. G. A.

Cystoseira abies-marina (reclassified as Gongolaria abies-marina) is a brown seaweed species rich in meroterpenoids, presenting interesting antioxidant, antitumor, and anti-inflammatory activities. However, there is still a lot to uncover regarding the bioactive potential of this species, as evidenced by the lack of records of antiaging activities from Cystoseira abies-marina, making this macroalga an excellent...


Xanthones for melanogenesis inhibition : Molecular docking and QSAR studies to ...

Rosa, Gonçalo P.; Palmeira, A.; Resende, Diana I. S. P.; Almeida, Isabel F.; Kane-Pagès, Aida; Barreto, Maria do Carmo; Sousa, E.; Pinto, Madalena M. M.

The human skin is constantly exposed to external factors that affect its integrity, UV radiation being one of the main stress factors. The repeated exposure to this radiation leads to increased production of Reactive Oxygen Species (ROS) which activate a series of processes involved in photoaging. Excessive UV exposure also exacerbates melanin production leading to a variety of pigmentation disorders. Xanthones...


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