11 documents found, page 1 of 2
T-cell branched glycosylation as a mediator of colitis-associated colorectal ca...
Leite-Gomes, E; Silva, MC; Dias, AM; Fernandes, Â; Faria, G; Nogueira, R; Santos-Pereira, B; Fernandes-Mendes, H; Azevedo, CM; Raposo, J; Portero, JLBackground and Aims: Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract, established as a risk factor for colorectal cancer (CRC) development. Long-standing inflammation appears to play a central role in colitis-associated colorectal cancer (CAC). However, the molecular mechanism underlying CAC progression is still elusive. Previous evidence showed that levels of b...
Transmural Remission Improves Clinical Outcomes Up to 5 years in Crohn's Disease
Raimundo Fernandes, S; Serrazina, J; Ayala Botto, I; Leal, T; Guimarães, A; Lemos Garcia, J; Rosa, I; Prata, R; Carvalho, D; Neves, J; Campelo, PIntroduction: Evidence supporting transmural remission (TR) as a long-term treatment target in Crohn's disease (CD) is still unavailable. Less stringent but more reachable targets such as isolated endoscopic (IER) or radiologic remission (IRR) may also be acceptable options in the long-term. Methods: Multicenter retrospective study including 404 CD patients evaluated by magnetic resonance enterography and colon...
mHealth Applications to Monitor Lifestyle Behaviors and Circadian Rhythm in Cli...
Rosa, I; Lages, M; Grilo, C; Barros, Renata; Guarino, MPMetabolic diseases are a global rising health burden, mainly due to the deleterious interaction of current lifestyles with the underlying biology of these diseases. Daily habits and behaviors, such as diet, sleep, and physical exercise impact the whole-body circadian system through the synchronization of the peripheral body clocks that contribute to metabolic homeostasis. The disruption of this system may promo...
Hyperbaric oxygen therapy as a complementary treatment for radiation proctitis:...
Alpuim Costa, D; Amaro, CE; Nunes, A; Cardoso, JS; Daniel, PM; Rosa, I; Branco, JVRadiotherapy (RT) is the backbone of multimodality treatment of more than half of cancer cases. Despite new modern RT techniques, late complications may occur such as radiation proctitis (RP). The natural history of RP is unpredictable. Minor symptoms may resolve spontaneously or require conservative treatment. On the other hand, for similar and uncomplicated clinical contexts, symptoms may persist and can even...
Hyperbaric oxygen therapy as a complementary treatment for radiation proctitis:...
Alpuim Costa, D; Amaro, CE; Nunes, A; Cardoso, JS; Daniel, PM; Rosa, I; Branco, JVRadiotherapy (RT) is the backbone of multimodality treatment of more than half of cancer cases. Despite new modern RT techniques, late complications may occur such as radiation proctitis (RP). The natural history of RP is unpredictable. Minor symptoms may resolve spontaneously or require conservative treatment. On the other hand, for similar and uncomplicated clinical contexts, symptoms may persist and can even...
Como Retomar a Atividade Cirúrgica Eletiva em Ortopedia Durante a Pandemia COVI...
Diogo, N; Miranda, A; Ruano, A; Mendes, E; Mendes, F; Montes, J; Alves, J; Rosa, I; Alegrete, N; Neves, N; Lourenço, P; Felicíssimo, P; Sá Cardoso, PEste documento foi elaborado pelo Colégio de Ortopedia da Ordem dos Médicos com o objetivo de estabelecer as orientações sobre a retoma da atividade cirúrgica programada em Ortopedia durante a pandemia COVID-19. As presentes normas de orientação: a) definem os critérios que permitem a priorização das cirurgias de acordo com a gravidade da situação clínica, com base em classificações existentes e publicadas; b) ...
How to resume elective orthopaedic surgical procedures during the COVID-19 pand...
Diogo, N; Miranda, A; Ruano, A; Mendes, E; Mendes, F; Montes, J; Alves, J; Rosa, I; Alegrete, N; Neves, N; Lourenço, P; Felicíssimo, P; Sá Cardoso, PThis document was prepared by the College of Orthopedics of the Portuguese Medical Association with the aim of developing the guidelines on the resumption of elective surgical activity in Orthopedics during the COVID-19 pandemic. It sets the criteria that allow the prioritization of surgeries according to the severity of the clinical situation, based on existing and published classifications. Moreover, it provi...
The performance of Remicade (R)-optimized quantification assays in the assessme...
Magro, F.; Rocha, C.; Vieira, A. I.; Sousa, H. T.; Rosa, I; Lopes, S.; Carvalho, J.; Dias, C. C.; Afonso, J.Background: The advent of Remicade (R) biosimilars, Remsima (R), Inflectra (R) and, more recently, Flixabi (R), has brought along the potential to decrease the costs associated with this therapy, therefore increasing its access to a larger group of patients. However, and in order to assure a soft transition, one must make sure the assays and algorithms previously developed and optimized for Remicade perform equ...
Proactive therapeutic drug monitoring of infliximab: a comparative study of a n...
Afonso, J; Lopes, S; Gonçalves, R; Caldeira, P; Lago, P; Tavares de Sousa, H; Ramos, J; Gonçalves, AR; Ministro, P; Rosa, I; Vieira, AI; Dias, CCBACKGROUND: Therapeutic drug monitoring is a powerful strategy known to improve the clinical outcomes and to optimise the healthcare resources in the treatment of autoimmune diseases. Currently, most of the methods commercially available for the quantification of infliximab (IFX) are ELISA-based, with a turnaround time of approximately 8 h, and delaying the target dosage adjustment to the following infusion. AI...
APPLICATION OF A RECENTLY DEVELOPED GEOTECHNICAL CARBON CALCULATOR
Sara Rios; Cristelo, N; da Fonseca, AV; Rosa, I; Ramos, CRecent research regarding soil stabilization has been increasingly concerned with environmental perfoimance. The present paper applies the newly developed CO2(eq) geotechnical calculator, created by the European Federation of Foundation Contractors and the The Deep Foundations Institute, to assess the behavior of three different binders used in the construction of cutter-soil mixing columns, which foamed an emb...