The exploitation of carbonate crystalline rocks in the Ossa-Morena Zone (OMZ) dates back more than two thousand years. Several historical exploitation poles in OMZ were identified based on the identification of distinctive marble lithotypes in Roman consumption areas, and some of those historical exploitation places were, subsequently, identified in situ through geo- archaeological works (e.g. Almadén de la Pla...
Rett Syndrome is an X-linked neurodevelopmental disorder (RTT; OMIM#312750) associated to MECP2 mutations. MeCP2 dysfunction is seen as one cause for the deficiencies found in brain-derived neurotrophic factor (BDNF) signaling, since BDNF is one of the genes under MeCP2 jurisdiction. BDNF signaling is also dependent on the proper function of the adenosinergic system. Indeed, both BDNF signaling and the adenosin...
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Objetivo: Sumariar a evidência acerca do efeito de programas de intervenção de fisioterapia na cognição e capacidade funcional de idosos. Metodologia: Pesquisa computadorizada nas bases de dados PubMed, PEDro e Web of Science de modo a selecionar estudos randomizados controlados que avaliassem o efeito de programas de intervenção de fisioterapia na cognição e capacidade funcional de idosos. Resultados: 7 estudo...
O objetivo geral do presente trabalho é: Analisar a possibilidade de retorno para a mesma atividade dos profissionais da saúde aposentados pela aposentadoria especial. O delineamento metodológico foi: exploratória, qualitativa, bibliográfica e documental. Os resultados e Conclusões são: A seguridade social é instituto destinado a proteção dos cidadãos contra riscos eventuais incluindo acidentes e doenças, promo...
Rett syndrome (RTT; OMIM#312750) is mainly caused by mutations in the X-linked MECP2 gene (methyl-CpG-binding protein 2 gene; OMIM*300005), which leads to impairments in the brain-derived neurotrophic factor (BDNF) signalling. The boost of BDNF mediated effects would be a significant breakthrough but it has been hampered by the difficulty to administer BDNF to the central nervous system. Adenosine, an endogenou...