3 documents found, page 1 of 1
Loss of Raf kinase inhibitor protein expression is associated with human papill...
Bidinotto, Lucas Tadeu; Véo, Carlos A. R.; Loaiza, Edgar Aleman; Ribeiro, Guilherme G.; Lorenzi, Adriana T.; Rosa, Luciana Albina ReisThere has been an increase in the incidence of anal cancer in the past two decades, with squamous cell carcinoma (SCC) being the most frequent histological type identified. Among the risk factors, high-risk human papillomavirus (HPV) infection is the most pervasive. Raf kinase inhibitor protein (RKIP) is expressed in a number of normal human tissues and previous studies have demonstrated the prognostic value of...
Characterization of topoisomerase II α and minichromosome maintenance protein 2...
Scapulatempo-Neto, Cristovam; Veo, Carlos; Fregnani, José Humberto T.G.; Lorenzi, Adriana; Mafra, Allini; Melani, Armando G.F.The present study aimed to ascertain the significance of topoisomerase II alpha (TOP2A) and minichromosome maintenance protein (MCM) 2 expression in anal carcinoma. A total of 75 anal lesions were retrieved from the files of the Department of Pathology of Barretos Cancer Hospital (Barretos, Brazil) in order to verify the human papillomavirus (HPV) statuses of these lesions and characterize the immunohistochemic...
Low mutation percentage of KRAS and BRAF genes in Brazilian anal tumors
Bidinotto, Lucas Tadeu; Veo, Carlos A. R.; Loaiza, Edgar Antonio Alemán; França, Alessandra Paulino Santos de; Lorenzi, Adriana TarlaAnal cancer is a rare type of digestive tract disease, which has had a crescent incidence in a number of regions. Carcinomas are most frequently found, with squamous cell carcinoma (SCC) comprising similar to 95% of all anal tumors. The major risk factor for development of this type of tumor is human papillomavirus (HPV) infection. However, previous studies have identified patients with anal cancer that are HPV...