4 documents found, page 1 of 1
Disability in activities of daily living and severity of dyskinesias determine ...
Coelho, Miguel; Abreu, Daisy; Correia-Guedes, Leonor; Lobo, Patrícia Pita; Fabbri, Margherita; Godinho, Catarina; Domingos, Josefa; Albuquerque, Luisa"BACKGROUND: There is scarce data on the level of handicap in Parkinson's disease (PD) and none in advanced stage PD. OBJECTIVE: To assess the handicap in advanced stage PD patients with disabling levodopa-induced motor complications selected to deep brain stimulation (DBS). METHODS: Data was prospectively recorded during routine evaluation for DBS. Handicap was measured using London Handicap Scale (LHS) (0 = m...
Neuromelanin magnetic resonance imaging of the Substantia Nigra in LRRK2-relate...
Guedes, Leonor Correia; Reimão, Sofia; Paulino, Patrícia; Nunes, Rita G.; Bouça-Machado, Raquel; Abreu, Daisy; Gonçalves, Nilza; Soares, Tiago
Convergence of miRNA expression profiling, α-synuclein interacton and GWAS in P...
Martins, Madalena; Rosa, Alexandra; Guedes, Leonor C.; Fonseca, Benedita V.; Gotovac, Kristina; Violante, Sara; Mestre, Tiago; Coelho, MiguelmiRNAs were recently implicated in the pathogenesis of numerous diseases, including neurological disorders such as Parkinson’s disease (PD). miRNAs are abundant in the nervous system, essential for efficient brain function and play important roles in neuronal patterning and cell specification. To further investigate their involvement in the etiology of PD, we conducted miRNA expression profiling in peripheral b...
Skin cancer and Parkinson’s disease
Ferreira, Joaquim J; Neutel, Dulce; Mestre, Tiago; Coelho, Miguel; Rosa, Mário M.; Rascol, Olivier; Sampaio, CristinaThe report of an increased frequency of melanoma during the clinical development of rasagiline prompted a renewed interest in a possible association between skin cancer and Parkinson's disease (PD). The evaluation of this risk ended in a recommendation to perform a periodic dermatological examination as a follow-up measure of their treatment. The recognition of this safety concern lead to the need to clarify if...