4 documents found, page 1 of 1
Loss of 5 '-Methylthioadenosine Phosphorylase (MTAP) is Frequent in High-Grade ...
Menezes, Weder Pereira de; Oliveira Silva, Viviane Aline; Faria Gomes, Izabela Natalia; Rosa, Marcela Nunes; Corcoll Spina, Maria LuisaMade available in DSpace on 2020-12-10T19:54:10Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-02-01; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Barretos Cancer Hospital; Public Ministry of Labor Campinas (Research, Prevention and Education of Occ...
Establishment, molecular and biological characterization of HCB-514: a novel hu...
Rosa, Marcela Nunes; Evangelista, Adriane Feijó; Leal, Letícia Ferro; De Oliveira, Cristina Mendes; Silva, Viviane Aline OliveiraCervical cancer is the fourth most common cancer in women. Although cure rates are high for early stage disease, clinical outcomes for advanced, metastatic, or recurrent disease remain poor. To change this panorama, a deeper understanding of cervical cancer biology and novel study models are needed. Immortalized human cancer cell lines such as HeLa constitute crucial scientific tools, but there are few other ce...
Semi-synthetic ingenol derivative from euphorbia tirucalli inhibits protein kin...
Silva, Viviane Aline Oliveira; Rosa, Marcela Nunes; Tansini, Aline; Martinho, Olga; Tanuri, Amilcar; Evangelista, Adriane FeijóThe identification of signaling pathways that are involved in gliomagenesis is crucial for targeted therapy design. In this study we assessed the biological and therapeutic effect of ingenol-3-dodecanoate (IngC) on glioma. IngC exhibited dose-time-dependent cytotoxic effects on large panel of glioma cell lines (adult, pediatric cancer cells, and primary cultures), as well as, effectively reduced colonies format...
In vitro screening of cytotoxic activity of euphol from Euphorbia tirucalli on ...
Silva, Viviane Aline Oliveira; Rosa, Marcela Nunes; Tansini, Aline; Oliveira, Renato J. S.; Martinho, Olga; Lima, João Paulo; Pianowski, Luiz FA large number of classic antineoplastic agents are derived from plants. Euphorbia tirucalli L. (Euphorbiaceae) is a subtropical and tropical plant, used in Brazilian folk medicine against many diseases, including cancer, yet little is known about its true anticancer properties. The present study evaluated the antitumor effect of the tetracyclic triterpene alcohol, euphol, the main constituent of E. tirucalli i...