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Prevascularized spongy-like hydrogels maintain their angiogenic potential after...

Ribeiro, Sara Cristina Freitas; Moreira, H.; da Silva, Lucília Pereira; Noro, Jennifer Martins; Sampaio-Marques, B.; Ludovico, Paula; Jarnalo, M.

The chronic shortage of organs and tissues for transplantation represents a dramatic burden on healthcare systems worldwide. Tissue engineering offers a potential solution to address these shortages, but several challenges remain, with prevascularization being a critical factor for in vivo survival and integration of tissue engineering products. Concurrently, a different challenge hindering the clinical impleme...


Effect of photobiomodulation on the behaviour of mesenchymal stem cells in thre...

Andrade, Ana Laura Martins de; da Silva, Lucília Pereira; Parizotto, Nivaldo Antonio; Brassolatti, Patrícia; Liebano, Richard Eloin; Marques, A. P.

Photobiomodulation (PBM) has been proposed as a strategy to improve the regenerative capacity of human adipose-derived stem cells (hASCs). Yet, this effect has been proved in 2D culture conditions. To analyze the effect of different doses of laser irradiation (660 nm) with different levels of energy (1 J, 2 J and 6 J) on hASCs cultured at 2D and 3D conditions. We used gellan gum spongy-like hydrogels as a bi...


Monocyte-derived macrophages and dermal fibroblasts-derived ECM making small talk

Chaves, S.; Macedo, J.; Reis, Daniel Pedro Pires Alves; Silva, Lucília Pereira; Marques, A. P.

[Excerpt] Introduction: 3D in vitro skin models allow studying molecular pathways that otherwise are only possible to explore using animal models. The incorporation of immune cells, such as macrophages, has been implemented to create immunocompetent analogues. Yet, the human biology representation in those models is limited, among other aspects, by the minimal extracellular matrix (ECM) mimicry[1]. In order to ...


Pre-selection of fibroblasts subsets prompt prevascularization of tissue engine...

Moreira, Helena R.; Cerqueira, Mariana T.; Silva, Lucília Pereira; Pires, Joana; Jarnalo, Mariana; Horta, Ricardo; Reis, R. L.; Marques, A. P.

Electronic supplementary information (ESI) available. See DOI: https://doi.org/10.1039/d2bm02022j; The papillary and reticular dermis harbors phenotypically distinct fibroblasts, whose functions such as maintenance of skin's microvasculature are also distinct. Thus, we hypothesized that pre-selection of the subpopulations of fibroblasts would benefit the generation of skin tissue engineered (TE) constructs, pro...


The hurdles of collagen shrinkage: a promising GelMA-based organotypic skin app...

Eltayari, Zahara Saoud Faria; Gasperini, Luca; Marques, A. P.

[Excerpt] Introduction: Collagen I (Col I) is the gold standard material to generate many in vitro tissue models, including organotypic skin. Col I remodeling by fibroblasts incorporated in the dermal part of the model leads to significant dimensional changes associated with additional hurdles when cultured within dynamic culture systems. These systems are relevant for the biofunctionality mimicry of the skin d...


Extracellular matrix in skin diseases: the road to new therapies

Malta, Mariana Jorge Oliveira Cardoso Denis; Cerqueira, Mariana Teixeira; Marques, A. P.

"Article in Press"; Background: The extracellular matrix (ECM) is a vital structure with a dynamic and complex organization that plays an essential role in tissue homeostasis. In the skin, the ECM is arranged into two types of com- partments: interstitial dermal matrix and basement membrane (BM). All evidence in the literature sup- ports the notion that direct dysregulation of the composition, abundance or stru...


Reflectance and fluorescence characteristics of PTFE coated with TPB at visible...

Haefner, J.; Fahs, A.; Ho, J.; Stanford, C.; Guenette, R.; Adams, C.; Almazán, H.; Álvarez, V.; Aparicio, B.; Aranburu, A.I.; Arazi, L.; Arnquist, I.J.

Polytetrafluoroethylene (PTFE) is an excellent diffuse reflector widely used in light collection systems for particle physics experiments. In noble element systems, it is often coated with tetraphenyl butadiene (TPB) to allow detection of vacuum ultraviolet scintillation light. In this work this dependence is investigated for PTFE coated with TPB in air for light of wavelengths of 200 nm, 260 nm, and 450 nm. Th...


Demonstration of neutrinoless double beta decay searches in gaseous xenon with ...

Fernandes, L. M. P.; Freitas, E. D. C.; Henriques, C. A. O.; Mano, R.D.P.; Monteiro, C. M. B.; Santos, J. M. F. dos; Teixeira, J. M. R.

The NEXT experiment aims at the sensitive search of the neutrinoless double beta decay in $^{136}$Xe, using high-pressure gas electroluminescent time projection chambers. The NEXT-White detector is the first radiopure demonstrator of this technology, operated in the Laboratorio Subterr\'aneo de Canfranc. Achieving an energy resolution of 1% FWHM at 2.6 MeV and further background rejection by means of the topolo...


A compact dication source for Ba2+ tagging and heavy metal ion sensor development

Navarro, K.E.; Baeza-Rubio, J.; Boyd, M.; Foss, F.W.; Giri, S.; Jones, B.J.P.; Miller, R.L.; Nygren, D.R.; Samaniego, F.J.; Stogsdill, K.

We present a tunable metal ion beam that delivers controllable ion currents in the picoamp range for testing of dry-phase ion sensors. Ion beams are formed by sequential atomic evaporation and single or multiple electron impact ionization, followed by acceleration into a sensing region. Controllability of the ionic charge state is achieved through tuning of electrode potentials that influence the retention time...


NEXT-CRAB-0: a high pressure gaseous xenon time projection chamber with a direc...

Borges, F. I. G. M.; Conde, C. A. N.; Escada, J.; Fernandes, L. M. P.; Freitas, E. D. C.; Henriques, C. A. O.; Mano, R.D.P.; Marques, A. P.

The search for neutrinoless double beta decay (0) remains one of the most compelling experimental avenues for the discovery in the neutrino sector. Electroluminescent gas-phase time projection chambers are well suited to 0 searches due to their intrinsically precise energy resolution and topological event identification capabilities. Scalability to ton- and multi-ton masses requires readout of large-area electr...


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