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Editorial comments on “Multiarray screening identifies plasma proteins associat...
Rufo, João Cavaleiro; Chauhan, Jitesh; Kalayci, Ömer; Eigenmann, Philippe; Cavaleiro Rufo, JoãoThe clinical associations between asthma and obesity remain poorly understood. The increasing prevalence ofboth conditions occurring may represent a modern clinical paradox. It is unclear whether reduced physical activ-ity in children with asthma leads to obesity, or if asthma-like symptoms in obese children result directly from theassociated excessive abdominal fat, impaired lung function, and heightened Th2 i...
Settled dust assessment in clinical environment: useful for the evaluation of a...
Viegas, Carla; Almeida, Beatriz; Monteiro, Ana; Paciência, Inês; Rufo, João Cavaleiro; Carolino, Elisabete; Gomes, Anita Quintal; Twarużek, MagdalenaThe collection and analysis of settled dust samples from indoor environments has become one of several environmental sampling methods used to assess bioburden indoors. The aim of the study was to characterize the bioburden in vacuumed settled dust from 10 Primary Health Care Centers by culture-based and molecular methods. Results for bacterial load ranged from 1 to 12 CFU.g−1 of dust and Gram-negative bacteria ...
Bacterial contamination in health care centers: differences between urban and r...
Monteiro, Ana; Almeida, Beatriz; Paciência, Inês; Rufo, João Cavaleiro; Ribeiro, Edna; Carolino, Elisabete; Viegas, Carla; Sousa-Uva, AntónioThis study aims to assess the airborne bioburden of rural and urban Portuguese Primary Health Care Centers (PHCC) using active and passive sampling methods and identify the potential differences in airborne microbiota between both environments. The highest total aerobic mesophilic bacterial load in indoor air was found in the Vaccination Room (448 CFU.m−3) in the Rural PHCC and in the Waiting Room (420 CFU.m−3)...
School environment associates with lung function and autonomic nervous system a...
Paciência, Inês; Rufo, João Cavaleiro; Silva, Diana; Martins, Carla; Mendes, Francisca; Rama, Tiago; Rodolfo, Ana; Madureira, Joana; Delgado, LuísChildren are in contact with local environments, which may affect respiratory symptoms and allergic sensitization. We aimed to assess the effect of the environment and the walkability surrounding schools on lung function, airway inflammation and autonomic nervous system activity. Data on 701 children from 20 primary schools were analysed. Lung function, airway inflammation and pH from exhaled breath condensate ...
Aspergillus spp. prevalence in one Portuguese hospital: a reason to be worried?
Viegas, Carla; Dias, Marta; Almeida, Beatriz; Paciência, Inês; Rufo, João Cavaleiro; Teixeira, João Paulo; Pereira, CristianaAspergillus genus is responsible for over 80% of pulmonary invasive fungal infections in humans. Invasive aspergillosis, caused by Aspergillus fumigatus in 80% of the cases, is the most common invasive fungal infection. The aim of this study was to assess the prevalence of Aspergillus genus in a Portuguese hospital, using a wide sampling approach combining active and passive methods. A total of 15 sampling site...
Hospital environment: a safe place to be when using Portuguese legislation as g...
Viegas, Carla; Almeida, Beatriz; Paciência, Inês; Rufo, João Cavaleiro; Pereira, CristianaExposure to bioburden (comprising bacteria and fungi) has become one of the critical issues for occupational and public health approaches in the hospital environment. This study aims to assess the fungal burden in one Central Hospital in Oporto, Portugal, applying the Indoor Air Quality (IAQ) Portuguese legislation as guidance, verifying both the limit values and the conformity established for general indoor en...
Exposure of children to ultrafine particles in primary schools in Portugal
Rufo, João Cavaleiro; Madureira, Joana; Paciência, Inês; Slezakova, Klara; Pereira, Maria do Carmo; Pereira, Cristiana; Teixeira, João PauloChildren spend a large part of their time at schools, which might be reflected as chronic exposure. Ultrafine particles (UFP) are generally associated with a more severe toxicity compared to fine and coarse particles, due to their ability to penetrate cell membranes. In addition, children tend to be more susceptible to UFP-mediated toxicity compared to adults, due to various factors including undeveloped immune...