61 documents found, page 1 of 7
Determination of Arylcyclohexylamines in Biological Specimens: Sensors and Samp...
Pelixo, Rodrigo; Barroso, Mário; Gallardo, Eugenia; Rosado, TiagoArylcyclohexylamine (ACH) compounds represent a predominant faction within new psychoactive substances. Due to their powerful dissociative effects, they are used in recreational contexts but also in situations of drug-facilitated sexual assault, and therefore, they are a constant target of analysis by forensic experts. In recent years, their consumption has been notably high, especially the use of ketamine, pre...
Determination of Antiepileptics in Biological Samples—A Review
Martinho, João; Simão, Ana Y.; Barroso, Mário; Gallardo, Eugenia; Rosado, TiagoEpilepsy remains a disease that affects many people around the world. With the development of new drugs to treat this condition, the importance of therapeutic drug monitoring continues to rise and remains a challenge for the medical community. This review article explores recent advances in the detection of antiepileptic drugs across various sample types commonly used for drug monitoring, with a focus on their ...
Characterisation of Cannabis-Based Products Marketed for Medical and Non-Medica...
Pires, Bruno; Oliveira, Patrik; Simão, Ana Y.; Reis, João; Ramos, Sofia; Duarte, Ana Paula; Margalho, Cláudia; Rosado, Tiago; Barroso, MárioCannabis-based products have gained attention in recent years for their perceived therapeutic benefits (with cannabinoids such as THC and CBD) and widespread availability. However, these products often lack accurate labelling regarding their cannabinoid content. Our study, conducted with products available in Portugal, revealed significant discrepancies between label claims and actual cannabinoid compositions. ...
Comparative study of sample preparation procedures to determine the main compou...
Gonçalves, Joana; Rosado, Tiago; Barroso, Mário; Restolho, José; Fernández, Nicolás; Luís, Ângelo; Gallardo, Eugenia; Duarte, Ana PaulaIntroduction : Ayahuasca is a psychoactive drink originally consumed by indigenous people of the Amazon. The lack of regulation of this drink leads to uncontrolled consumption, and it is often consumed in religious contexts. Objective :The aim of this work is to compare three miniaturised extraction techniques for extracting the main ayahuasca compounds from beverages. Methodology:Three sample pretreatment tech...
Opioid Monitoring in Clinical Settings: Strategies and Implications of Tailored...
Rosendo, Luana M.; Rosado, Tiago; Zandonai, Thomas; Rincon, Karem; Peiró, Ana M.; Barroso, Mário; Gallardo, EugeniaThis review emphasises the importance of opioid monitoring in clinical practice and advocates for a personalised approach based on pharmacogenetics. Beyond effectively managing pain, meticulous oversight is required to address concerns about side effects, specially due to opioid-crisis-related abuse and dependence. Various monitoring techniques, along with pharmacogenetic considerations, are critical for person...
Volumetric Absorptive Microsampling in Toxicology
Pires, Bruno; Catarro, Gonçalo; Soares, Sofia; Gonçalves, Joana; Rosado, Tiago; Barroso, Mário; Araujo, André R. T. S.; Gallardo, EugeniaVolumetric absorptive microsampling (VAMS) is an emerging technique in clinical and forensic toxicology. It is recognized as a promising alternative to traditional sampling methods, offering an accurate and minimally invasive means of collecting small volumes of biological samples, such as blood, urine, and saliva. Unlike conventional methods, VAMS provides advantages in terms of sample stability, storage, and ...
Quantification of antidepressants in oral fluid and plasma samples using microe...
Soares, Sofia; Rosado, Tiago; Barroso, Mário; Gallardo, EugeniaThe consumption of antidepressants is extremely significant as they are a class of medications widely used in the treatment of numerous disorders and are therefore considered a public health problem throughout the world. The aim of this work was to develop and optimize two methodologies for the determination of selected antidepressants and metabolites (fluoxetine, venlafaxine, O-desmethylvenlafaxine, citalopram...
Comparative study of sample preparation procedures to determine the main compou...
Gonçalves, Joana; Rosado, Tiago; Barroso, Mário; Restolho, José; Fernández, Nicolás; Luís, Ângelo; Gallardo, Eugenia; Duarte, Ana PaulaIntroduction Ayahuasca is a psychoactive drink originally consumed by indigenous people of the Amazon. The lack of regulation of this drink leads to uncontrolled consumption, and it is often consumed in religious contexts. Objective The aim of this work is to compare three miniaturised extraction techniques for extracting the main ayahuasca compounds from beverages. Methodology Three sample pretreatment techniq...
Microextraction action by packed sorbent in forensic drug analysis
Rosado, Tiago; Pelixo, Rodrigo; Pires, Bruno; Catarro, João Miguel; Rosendo, Luana M.; Brinca, Ana T.; Antunes, Mónica; Soares, Sofia; Simão, Ana Y.Microextraction by packed sorbent (MEPS) efficiently combines extraction, pre-concentration, and cleanup in a single device comprising two parts: the MEPS syringe and the packed sorbent bed1. MEPS has been used for several bioanalytical applications, including extraction of endogenous metabolites, biomarkers, and drugs from biological samples. It is particularly useful in metabolomics and pharmacokinetic studie...
Monitorização de antidepressivos: comparação de dois métodos de extração em amo...
Soares, Sofia; Rosado, Tiago; Barroso, Mário; Gallardo, EugeniaO consumo de antidepressivos representa uma problemática mundial, apresentando Portugal uma das taxas de prevalência de doenças mentais mais elevadas da Europa1. A monitorização terapêutica é instituída para um pequeno número de fármacos para os quais existe uma relação direta entre a concentração e o efeito farmacológico. Este trabalho compara duas metodologias desenvolvidas para a determinação de antidepressi...