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Epidemiology and risk factors for hyperkalaemia in heart failure

Grobbee, Diederick E.; Filippatos, Gerasimos; Desai, Nihar R.; Coats, Andrew J. S.; Pinto, Fausto J.; Rosano, Giuseppe M. C.; Cleland, John G. F.

Patients with heart failure (HF), particularly those with impaired renal function receiving renin-angiotensin-aldosterone system inhibitors (RAASis), are at risk of hyperkalaemia; when hyperkalaemia is severe, this can have serious clinical consequences. The incidence, prevalence, and risk factors for hyperkalaemia reported in randomized trials of RAASis may not reflect clinical practice due to exclusion of pat...


Single-pill combination in the management of chronic coronary syndromes: a stra...

Pinto, Fausto J.; Piepoli, Massimo F.; Ferrari, Roberto; Tsioufis, Konstantinos; Rosano, Giuseppe M. C.; Nedoshivin, Aleksandr; Kaski, Juan Carlos

Chronic coronary syndrome (CCS) represents a major challenge for physicians, particularly in the context of an increasing aging population. Additionally, CCS is often underestimated and under-recognised, particularly in female patients. As patients are frequently affected by several chronic comorbidities requiring polypharmacy, this can have a negative impact on patients' adherence to treatment. To overcome thi...


Patient profiling in heart failure for tailoring medical therapy: a consensus d...

Rosano, Giuseppe M. C.; Moura, Brenda; Metra, Marco; Böhm, Michael; Bauersachs, Johann; Ben Gal, Tuvia; Adamopoulos, Stamatis; Abdelhamid, Magdy

Despite guideline recommendations and available evidence, implementation of treatment in heart failure (HF) is poor. The majority of patients are not prescribed drugs at target doses that have been proven to positively impact morbidity and mortality. Among others, tolerability issues related to low blood pressure, heart rate, impaired renal function or hyperkalaemia are responsible. Chronic kidney disease plays...


Anti-anginal drugs–beliefs and evidence : systematic review covering 50 years o...

Ferrari, Roberto; Pavasini, Rita; Camici, Paolo G.; Crea, Filippo; Danchin, Nicolas; Pinto, Fausto J.; Manolis, Athanasios; Marzilli, Mario

Chronic stable angina is the most prevalent symptom of ischaemic heart disease and its management is a priority. Current guidelines recommend pharmacological therapy with drugs classified as being first line (beta blockers, calcium channel blockers, short acting nitrates) or second line (long-acting nitrates, ivabradine, nicorandil, ranolazine, and trimetazidine). Second line drugs are indicated for patients wh...


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