5 documents found, page 1 of 1
Type 2 diabetes-related variants influence the risk of developing multiple myel...
Ríos, Rafael; Lupiañez, Carmen Belén; Campa, Daniele; Martino, Alessandro; Martínez-López, Joaquin; Martínez-Bueno, Manuel; Varkonyi, JuditType 2 diabetes (T2D) has been suggested to be a risk factor for multiple myeloma (MM), but the relationship between the two traits is still not well understood. The aims of this study were to evaluate whether 58 genome-wide-association-studies (GWAS)-identified common variants for T2D influence the risk of developing MM and to determine whether predictive models built with these variants might help to predict ...
Genetic variants and multiple myeloma risk : IMMEnSE validation of the best rep...
Martino, Alessandro; Campa, Daniele; Jurczyszyn, Artur; Martínez-Lopez, Joaquín; Moreno, Maria José; Varkonyi, Judit; Dumontet, CharlesBACKGROUND: Genetic background plays a role in multiple myeloma susceptibility. Several single-nucleotide polymorphisms (SNP) associated with genetic susceptibility to multiple myeloma were identified in the last years, but only a few of them were validated in independent studies. METHODS: With the aim to conclusively validate the strongest associations so far reported, we selected the polymorphisms rs2227667 (...
Polymorphisms in regulators of xenobiotic transport and metabolism genes PXR an...
Martino, Alessandro; Sainz, Juan; Reis, R. M.; Moreno, Victor; Buda, Gabriele; Lesueur, Fabienne; Marques, Herlander; Garcıía-Sanz, Ramón; Ríos, RafaelThe exposure to pesticides and toxic compounds in xenobiotic transport and metabolism genes has been shown to affect risk of developing multiple myeloma (MM). Therefore, we hypothesized that genetic variations in xenobiotic transport and metabolism regulator genes PXR (NR1I2) and CAR (NR1I3) could determine a difference in MM susceptibility. Ten tagging single-nucleotide polymorphisms (SNPs) for PXR and seven f...
Impact of polymorphic variation at 7p15.3, 3p22.1 and 2p23.3 loci on risk of mu...
Reis, R. M.; Martino, Alessandro; Campa, Daniele; Jamroziak, Krzysztof; Sainz, Juan; Buda, Gabriele; García-Sanz, Ramón; Lesueur, Fabienne
Genetics and molecular epidemiology of multiple myeloma : the rationale for the...
Martino, Alessandro; Sainz, Juan; Buda, Gabriele; Jamroziak, Krzysztof; Reis, R. M.; García-Sanz, Ramón; Jurado, Manuel; Ríos, RafaelThere is strong evidence suggesting the presence of a genetic component in the aetiology of multiple myeloma (MM). However no genetic risk factors have been unequivocally established so far. To further our understanding of the genetic determinants of MM risk, a promising strategy is to collect a large set of patients in a consortium, as successfully done for other cancers. In this article, we review the main fi...