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Leprosy detection rate in patients under immunosuppression for the treatment of...
Barroso, Daniel Holanda; Brandão, Jurema Guerrieri; Andrade, Elaine Silva Nascimento; Correia, Ana Clara Banhatto; Aquino, Danielle CostaBackground: Recently developed immunosuppressive drugs, especially TNF antagonists, may enhance the risk of granulomatous infections, including leprosy. We aimed to evaluate the leprosy detection rate in patients under immunosuppression due to rheumatological, dermatological and gastroenterological diseases. Methods: We performed a systematic review of the literature by searching the PubMed, EMBASE, LILACS, Web...
A comprehensive systematic review of leishmaniasis in patients undergoing drug-...
Kurizky, Patricia Shu; Marianelli, Fernanda Ferraço; Cesetti, Mariana Vicente; Damiani, Giovanni; Sampaio, Raimunda Nonata RibeiroImmunosuppression is an important risk factor for leishmaniasis. We assessed the clinical profile, geographic distribution and prevalence of leishmaniasis in patients undergoing immunosuppressive therapy for dermatological, rheumatological or gastroenterological autoimmune diseases. We identified relevant studies in PubMed, EMBASE, Scopus, Web of Science and LILACS on July 3rd, 2018. We included articles that r...
A randomized, open-label clinical trial comparing the long-term effects of milt...
Sampaio, Raimunda Nonata Ribeiro; Silva, Juliana Saboia Fontenele e; Paula, Carmen Dea Ribeiro de; Porto, CláudiaINTRODUCTION: The treatment of mucosal leishmaniasis (ML) is difficult due to the toxicity and route of administration of standard drugs. Miltefosine is an oral agent used for leishmaniasis treatment; however, no data exist regarding its use for ML in Brazil. In this study, we aimed to evaluate the efficacy of miltefosine for ML treatment compared to that of pentavalent antimonial in a pilot study. METHODS: We ...
A comprehensive systematic review of leishmaniasis in patients undergoing drug-...
Kurizky, Patrícia Shu; Marianelli, Fernanda Ferraço; Cesetti, Mariana Vicente; Damiani, Giovanni; Sampaio, Raimunda Nonata RibeiroImmunosuppression is an important risk factor for leishmaniasis. We assessed the clinical profile, geographic distribution and prevalence of leishmaniasis in patients undergoing immunosuppressive therapy for dermatological, rheumatological or gastroenterological autoimmune diseases. We identified relevant studies in PubMed, EMBASE, Scopus, Web of Science and LILACS on July 3rd, 2018. We included articles that r...
American cutaneous leishmaniasis triggered by electrocoagulation
Martins, Sofia Sales; Santos, Adriana de Oliveira; Lima, Beatriz Dolabela; Gomes, Ciro Martins; Sampaio, Raimunda Nonata RibeiroCutaneous leishmaniasis is usually transmitted by infected phlebotomine sand fly bites that initiate local cutaneous lesions. Few reports in the literature describe other modes of transmission. We report a case of a previously healthy 59-year-old woman who underwent electrocoagulation to remove seborrheic keratosis confirmed by dermatoscopy. Three months later, a skin fragment tested positive for Leishmania cul...
PD-L1 may mediate T-cell exhaustion in a case of early diffuse Leishmaniasis ca...
Barroso, Daniel Holanda; Falcão, Sarah de Athayde Couto; Motta, Jorgeth de Oliveira Carneiro da; Santos, Laís Sevilha dosIntroduction: Diffuse cutaneous leishmaniasis (DCL) is a rare disease form associated with Leishmania (L.) amazonensis in South America. It represents the “anergic” pole of American Tegumentary Leishmaniasis, and the explanation for its resistance to treatment remains elusive. We aimed to study some possible immunological mechanisms involved in the poor DCL treatment response by evaluating some cell surface mol...
Tratamento da forma mucosa de leishmaniose sem resposta a glucantime, com anfot...
Sampaio, Raimunda Nonata Ribeiro; Marsden, Philip DavisTratamos com ambisome (2 a 5g totais de dose) seis pacientes com leishmaniose mucosa sem resposta a tratamento com glucantime (20mg SbV/kg/dia). A dose diária usada foi 2 a 3mg/kg/dia, aplicada por um mínimo de 20 dias. Após 26 a 38 meses de acompanhamento, cinco pacientes estão clinicamente curados. Um recidivou aos 6 meses. Não foram observados efeitos colaterais além de cefaléia, após a injeção. O ambisome c...
Field validation of a Leishmania (Leishmania) mexicana exo-antigens ELISA for d...
Soares, Killarney Ataide; Urdapilleta, Ada Amália Ayala; Santos, Gilcilene Maria dos; Carneiro, Andréa Lisboa; Gomes, Ciro Martins; Roselino, Ana MariaBackground: several tests are performed to obtain better accuracy when diagnosing American tegumentary leishmaniasis (ATL). It is believed that antigens released via secretion, excretion and metabolism are more specific than are antigens released by the lysis of Leishmaniaparasites. Such antigens are known as exo-antigens (exo-Ag) and are formed from products released by cultured parasites in a way that is simi...
Accuracy of mucocutaneous leishmaniasis diagnosis using polymerase chain reacti...
Gomes, Ciro Martins; Mazin, Suleimy Cristina; Santos, Elisa Raphael dos; Cesetti, Mariana Vicente; Bächtold, Guilherme Albergaria BrízidaThe diagnosis of mucocutaneous leishmaniasis (MCL) is hampered by the absence of a gold standard. An accurate diagnosis is essential because of the high toxicity of the medications for the disease. This study aimed to assess the ability of polymerase chain reaction (PCR) to identify MCL and to compare these results with clinical research recently published by the authors. A systematic literature review based on...
Effectiveness of miltefosine-pentoxifylline compared to miltefosine in the trea...
Santarem, Ana Angélica Amorim; Greggianin, Gabriel Frizon; Debastiani, Rafaela Garcia; Ribeiro, Jefferson Bruno Pereira; Polli, Demerson AndreIntroduction The treatment of leishmaniasis ischallenging, given the difficulties in drug administration and resistance. Therefore, we chose to test the efficacy of miltefosine combined with pentoxifylline. Methods Twenty-seven isogenic C57Bl/6 mice were infected with Leishmania (Leishmania) amazonensis, and equally divided into three groups: miltefosine (200mg/kg/day), miltefosine (200mg/kg/day) with pentoxify...