4 documents found, page 1 of 1
Hereditary gastric and breast cancer syndromes related to CDH1 germline mutatio...
Corso, G; Montagna, G; Figueiredo, J; Vecchia, CL; Romario, UF; Fernandes, MS; Seixas, S; Roviello, F; Trovato, C; Guerini-Rocco, E; Fusco, NE-cadherin (CDH1 gene) germline mutations are associated with the development of diffuse gastric cancer in the context of the so-called hereditary diffuse gastric syndrome, and with an inherited predisposition of lobular breast carcinoma. In 2019, the international gastric cancer linkage consortium revised the clinical criteria and established guidelines for the genetic screening of CDH1 germline syndromes. Nev...
O-glycan truncation enhances cancer-related functions of CD44 in gastric cancer.
Mereiter, S; Macedo, JA; Polom, K; Roviello, F; Magalhães, A; Reis, CACD44 isoforms are often upregulated in gastric cancer and have been associated with increased metastatic potential and poor survival. To evaluate the functional impact of O-glycan truncation on CD44 we have analysed glyco-engineered cancer cell models displaying shortened O-glycans. Here, we demonstrate that induction of aberrant O-glycan termination through various molecular mechanisms affects CD44 molecular f...
Epitope mapping of a new anti-Tn antibody detecting gastric cancer cells.
Persson, N; Stuhr-Hansen, N; Risinger, C; Mereiter, S; Polónia, A; Polom, K; Kovács, A; Roviello, F; Reis, CA; Welinder, C; Danielsson, L; Jansson, BHere, we introduce a novel scFv antibody, G2-D11, specific for two adjacent Tn-antigens (GalNAc- Ser/Thr) binding equally to three dimeric forms of the epitope, Ser-Thr, Thr-Thr and Thr-Ser. Compared to other anti-Tn reagents, the binding of G2-D11 is minimally influenced by the peptide structure, which indicates a high degree of carbohydrate epitope dominance and a low influence from the protein backbone. With...
Somatic mutations and deletions of the E-cadherin gene predict poor survival of...
Corso, G; Carvalho, J; Marrelli, D; Vindigni, C; Carvalho, B; Seruca, R; Roviello, F; Oliveira, CPurpose The prognosis of gastric cancer (GC) is poor, and the molecular pathogenesis players are vastly unknown. Surgery remains the primary option in GC treatment. The aim of this study was to investigate the impact of somatic CDH1 alterations in prognosis and survival of patients with GC. Patients and Methods A series of patients with sporadic and familial GC (diffuse and intestinal; n _ 246) were analyzed fo...