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Zebrafish Model as a Screen to Prevent Cyst Inflation in Autosomal Dominant Pol...

Oliveira, I; Jacinto, R; Pestana, S; Nolasco, F; Calado, J; Lopes, SS; Roxo-Rosa, M

In autosomal dominant polycystic kidney disease (ADPKD), kidney cyst growth requires the recruitment of CFTR (cystic fibrosis transmembrane conductance regulator), the chloride channel that is defective in cystic fibrosis. We have been studying cyst inflation using the zebrafish Kupffer's vesicle (KV) as model system because we previously demonstrated that knocking down polycystin 2 (PC2) induced a CFTR-mediate...

Date: 2021   |   Origin: Repositório do Centro Hospitalar de Lisboa Central, EPE
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