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Acute physical exercise increases leptin-induced hypothalamic extracellular sig...
Gaspar, Rafael Calais, 1992-; Muñoz, Vitor Rosetto, 1993-; Nakandakari, Susana Castelo Branco Ramos; Minuzzi, Luciele Guerra; Botezelli, José DiegoAgradecimentos: The authors thank Obesity and Comorbidities Research Center – OCRC and FAPESP (2016/18488-8) and CNPq (306535/2017-3) for all support during the experiment; The obesity is a result of energy imbalance and the increase in thermogenesis seems an interesting alternative for the treatment of this disease. The mechanism of energy expenditure through thermogenesis is tightly articulated in the hypotha...
Immune-endocrine responses and physical performance of master athletes during t...
Minuzzi, Luciele Guerra; Gaspar, Rafael Calais, 1992-; Muñoz, Vitor Rosetto, 1993-; Pauli, José Rodrigo, 1979-Agradecimentos: Firstly, the authors would like to thank all the master athletes that volunteered to participate in this study. The Research Center for Sport and Physical Activity (UID/DTP/04213/2016), Faculty of Sports Sciences and Physical Education, and the University of Coimbra funded the study. Also, the present manuscript was accomplished with support from CAPES, Coordination for the Improvement of Higher...
TGF-ß1 downregulation in the hypothalamus of obese mice through acute exercise
Silva, Vagner Ramon Rodrigues, 1985-; Lenhare, Luciene, 1984-; Katashima, Carlos Kiyoshi, 1976-; Morari, Joseane, 1982-Agradecimentos: We thank the São Paulo Foundation Research (FAPESP), Coordination for the Improvement of Higher Education Personnel (CAPES) and Obesity and Comorbidities Research Center (OCRC) for technical and financial support; Abstract: Obesity and aging lead to abnormal transforming growth factor-ß1 (TGF-ß1) signaling in the hypothalamus, triggering the imbalance on glucose metabolism and energy homeostasis...
Hippocampal insulin signaling and neuroprotection mediated by physical exercise...
Botezelli, José Diego; Gaspar, Rafael Calais, 1992-; Pauli, José Rodrigo, 1979-Abstract: Epidemiological studies indicate continuous increases in the prevalence of Alzheimer’s Disease (AD) in the next few decades. The key feature of this disease is hippocampal neurodegeneration. This structure has an important role in learning and memory. Intense research efforts have sought to elucidate neuroprotective mechanisms responsible for hippocampal integrity. Insulin signaling seems to be a very...
Hypothalamic endoplasmic reticulum stress of overtrained mice after recovery
Moura, Leandro Pereira de, 1985-; Pauli, José Rodrigo, 1979-Agradecimentos: The present work received financial support from the São Paulo Research Foundation (FAPESP; process numbers 2013/19985-7, 2013/20591-3, 2014/25459-9, 2015/08013-0 and 2015/13275-3); Abstract: Knowing the relationship between endoplasmic reticulum (ER) stress and inflammation and based on the fact that downhill running-based overtraining (OT) model increases hypothalamus levels of some pro-inflam...
Nonfunctional overreaching and hepatic adaptations of APPL1 and APPL2
Pauli, José Rodrigo, 1979-Agradecimentos: The present work received financial support from the São Paulo Research Foundation (FAPESP; process numbers 2013/19985-7, 2013/20591-3, 2014/25459-9, 2015/08013-0 and 2015/13275-3); Abstract: Previously, we verified that overtrained mice upregulated the TRB3 levels, its association with Akt, and the hepatic concentrations of glycogen. It is known that APPL1 can limit the interaction between TRB3...
Molecular mechanisms of glucose uptake in skeletal muscle at rest and in respon...
Pereira, Rodrigo Martins, 1988-; Moura, Leandro Pereira de, 1985-; Muñoz, Vitor Rosetto, 1993-; Gaspar, Rodrigo Stellzer, 1991-Agradecimentos: The authors thank FAPESP, for its indispensable support; Abstract: Glucose uptake is an important phenomenon for cell homeostasis and for organism health. Under resting conditions, skeletal muscle is dependent on insulin to promote glucose uptake.Insulin, after binding to its membrane receptor, triggers a cascade of intracellular reactions culminating in activation of the glucose transporter 4, ...
Acute physical exercise increases glucose uptake in skeletal muscle of old rats...
Muñoz, Vitor Rosetto, 1993-; Moura, Leandro Pereira de, 1985-; Gaspar, Rafael Calais, 1992-; Silva, Vagner Ramon Rodrigues, 1985-Abstract: Senescence promotes several metabolic disorders, including insulin resistance (IR). It is known that physical exercise is an important non-pharmacological agent in the prevention and treatment of IR and consequently reducing the incidence of T2DM. Rho-kinase (Rock) has been postulated as an important protein that acts directly on the phosphorylation of IRS-1, collaborating up to 50% of glucose uptake ...
Treadmill training increases SIRT-1 and PGC-1a protein levels and AMPK phosphor...
Pauli, José Rodrigo, 1979-; Ropelle, Eduardo Rochete, 1976-Agradecimentos: This work was supported by Conselho Nacional de Desenvolvimento Cient'?fico e Tecnologico (CNPq) and Universi- ' dade do Extremo Sul Catarinense (UNESC); Abstract: The present study investigated the effects of running at 0.8 or 1.2?km/h on inflammatory proteins (i.e., protein levels of TNF-a, IL-1ß, and NF-?B) and metabolic proteins (i.e., protein levels of SIRT-1 and PGC-1a, and AMPK phosphoryl...
Efeitos do destreinamento e da dieta hiperlipidica nos mecanismo moleculares de...
Pauli, José Rodrigo, 1979-Orientador: Mario Jose Abdalla Saad; Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas; Resumo: A cessação do treinamento físico (destreinamento) resulta em rápido acréscimo da massa adiposa, ganho de peso e resistência à insulina tanto em humanos quanto em animais. No entanto, os mecanismos moleculares envolvidos nesse processo permanecem desconhecidos. Diferentes proteínas in...