35 documents found, page 1 of 4
Pediatric, adult, and late onset multiple sclerosis: Cognitive phenotypes and g...
De Meo, E; Portaccio, E; Cortese, R; Ruano, L; Goretti, B; Niccolai, C; Patti, F; Chisari, C; Gallo, P; Grossi, P; Ghezzi, A; Roscio, M; Mattioli, F" Objectives: We aim to investigate cognitive phenotype distribution and MRI correlates across pediatric-, elderly-, and adult-onset MS patients as a function of disease duration. Methods: In this cross-sectional study, we enrolled 1262 MS patients and 238 healthy controls, with neurological and cognitive assessments. A subset of 222 MS patients and 92 controls underwent 3T-MRI scan for brain atrophy and lesion...
Validation of a web-based self-administered test for cognitive assessment in a ...
Rystedt, E; Morén, J; Lindback, J; Cruz, VT; Ingelsson, M; Kilander, L; Lunet, N; Pais, J; Ruano, L; Westman, GComputerized cognitive tests have the potential to cost-effectively detect and monitor cognitive impairments and thereby facilitate treatment for these conditions. However, relatively few of these tests have been validated in a variety of populations. Brain on Track, a selfadministered web-based test, has previously been shown to have a good ability to differentiate between healthy individuals and patients with...
Life-course socio-economic status and its impact on functional health of Portug...
Henriques, A; Ruano, L; Fraga, S; Soares, S; Barros, H; Talih, MFunctional health is arguably one of the most important health indicators for older adults, because it assesses physical, cognitive and social functions in combination. However, life-course circumstances may impact this multidimensional construct. The aim of the present study was to assess the relationship between life-course socio-economic status (SES) and different dimensions of functional health in older adu...
One-year regional brain volume changes as potential predictors of cognitive fun...
Meira, T; Coelho, A; Onat, S; Ruano, L; Cerqueira, JJBackgroundThe most reliable magnetic resonance imaging (MRI) marker of cognitive dysfunction in multiple sclerosis (MS) is brain atrophy. However, 1-year volumetric changes prior to cognitive assessment were never studied as potential predictors of cognition, which we aim to assess with this pilot work.MethodsTwenty-two MS patients were submitted to a baseline measure of 83 regional brain volumes with MRI and r...
Long-term neurological complications in COVID-19 survivors: study protocol of a...
Araújo, N; Silva, I; Campos, P; Correia, R; Calejo, M; Freitas, P; Seco, M; Ribeiro, L; Costa, AR; Morais, S; Pereira, S; Firmino-Machado, JBackgroundEvidence suggests an association between SARS-CoV-2 infection and worse performance on cognitive tests, and a higher risk of Parkinson's disease (PD) and dementia up to 6 and 12 months after infection, respectively. Longer follow-ups with comparison groups are needed to clarify the potentially increased risk of neurodegenerative diseases in COVID-19 survivors, namely those infected before mass vaccina...
Anxiety and Depression in Patients with Prostate Cancer, at Cancer Diagnosis an...
Duarte, V; Araújo, N; Lopes, C; Costa, A; Ferreira, A; Carneiro, F; Oliveira, J; Braga, I; Morais, S; Pacheco Figueiredo, L; Ruano, L; Tedim Cruz, VTProstate cancer (PCa) is the most prevalent among men, and psychological symptoms may affect many patients. This study aims to describe the prevalence of probable anxiety and depression before PCa treatments and after one year and to identify sociodemographic and clinical factors associated with these outcomes. Between February 2018 and March 2020, 292 patients recently diagnosed with PCa were recruited at the ...
Cognitive impairment and markers of optical neurodegeneration in early multiple...
Silva, R; Coelho, P; Seabra, M; Laranjinha, I; Vieira, D; Costa, O; Jesus, J; Fonseca, AC; Costa, S; Ferreira, I; Lemos, J; Sousa, C; Vale, J; Sá, MJIntroduction: Cognitive impairment and retinal atrophy have been proposed as two potential markers of neurodegeneration in multiple sclerosis (MS). We aimed at assessing the relation between peripapillary retinal nerve fiber layer (pRNFL) and macular ganglion cell layer (mGCL) atrophy and cognitive performance in early MS. Methods: This is a multicenter cross-sectional study on patients with early MS (clinicall...
Androgen-deprivation therapy and cognitive decline in the NEON-PC prospective s...
Araújo, N; Costa, A; Lopes-Conceição, L; Ferreira, A; Carneiro, F; Oliveira, J; Braga, I; Morais, S; Pacheco-Figueiredo, L; Ruano, L; Cruz, VTBackground: Androgen-deprivation therapy (ADT) has been associated with cognitive decline, but results are conflicting. This study describes changes in cognitive performance in patients with prostate cancer, according to ADT, during the first year after prostate cancer diagnosis. Patients and methods: Patients with prostate cancer treated at the Portuguese Institute of Oncology of Porto (n = 366) were evaluated...
Prevalence of Cognitive Impairment before Prostate Cancer Treatment
Araújo, N; Costa, A; Lopes, C; Lopes-Conceição, L; Ferreira, A; Carneiro, F; Oliveira, J; Morais, S; Pacheco-Figueiredo, L; Ruano, L; Cruz, VTCognitive impairment is common among patients with different types of cancer, even before cancer treatment, but no data were reported among patients with prostate cancer (PCa), who may be at high risk due to advanced age. This study aims to estimate the prevalence of cognitive impairment before PCa treatment. Between February 2018 and April 2021, the NEON-PC cohort recruited 605 patients with PCa proposed for t...
Interchangeability of two versions of the Montreal Cognitive Assessment for the...
Araújo, N; Lopes-Conceição, L; Morais, S; Fontes, F; Dias, T; Cruz, VT; Ruano, L; Pereira, S; Lunet, NPurpose: The cognitive performance of patients with breast cancer (BCa) may be affected by cancer and its treatments. The Montreal Cognitive Assessment (MoCA) is a widely used cognitive impairment screening tool, but practice effects must be considered for longitudinal assessments. Since learning effects could be overcome through the alternate use of two versions of the MoCA, we aimed to explore their interchan...