26 documents found, page 1 of 3
Excision repair SNPs may influence the extent of DNA damage from radioiodine th...
Santos, Luís Silva; Gil, Otávia Monteiro; Silva, Susana Nunes; Gomes, Bruna Costa; Ferreira, Teresa; Limbert, Edward; Rueff, José
O ensino da Medicina – Algumas Premissas em Busca de Uma Epistemologia do Ensin...
Rueff, José
New “Omics” Approaches as Tools to Explore Mechanistic Nanotoxicology
Ventura, Célia; Torres, Vukosava; Vieira, Luís; Gomes, Bruno; Rodrigues, António Sebastião; Rueff, José; Penque, Deborah; Silva, Maria JoãoIn the last years, “omics” approaches have been applied to study the toxicity of nanomaterials (NM) with the aim of obtaining insightful information on their biological effects. One of the most developed “omics” field, transcriptomics, expects to find unique profiles of differentially expressed genes after exposure to NM that, besides providing evidence of their mechanistic mode of action, may also be used as b...
Doenças genéticas na Pintura: a arte parecida com a vida – do Renascimento ao B...
Rueff, José
Bactérias ‘humanizadas’: expressão de genes humanos em procariotas na detecção ...
Rueff, José
Pandemia SARS-CoV-2
Rueff, José; Soares, Jorge; Miguel, José Pereira; Rodrigues, Fernando Carvalho
Micronuclei formation upon radioiodine therapy for well-differentiated thyroid ...
Santos, Luís S.; Gil, Octávia M.; Silva, Susana N.; Gomes, Bruno C.; Ferreira, Teresa C.; Limbert, Edward; Rueff, JoséRadioiodine therapy with131I remains the mainstay of standard treatment for well-differentiated thyroid cancer (DTC). Prognosis is good but concern exists that131I-emitted ionizing radiation may induce double-strand breaks in extra-thyroidal tissues, increasing the risk of secondary malignancies. We, therefore, sought to evaluate the induction and 2-year persistence of micronuclei (MN) in lymphocytes from 26131...
Professor João Fraga de Azevedo – a contribution to the profile of a major char...
Rueff, JoséThe author evokes the historical figure of João Fraga de Azevedo, paying compliment to his continuous quest for medical knowledge and his high etichal and moral standards, recognizing in him a major character in Tropical Medicine.; O autor evoca a figura histórica de João Fraga de Azevedo, relevando a sua constante busca de conhecimento médico e elevados padrões éticos e morais, reconhecendo nele uma figura mai...
Efeitos genéticos das radiações ionizantes
Rueff, José
Thyroid cancer: the quest for genetic susceptibility involving DNA repair genes
Santos, Luís S.; Gomes, Bruno Costa; Bastos, Hélder N.; Gil, Octávia M.; Azevedo, Ana Paula; Ferreira, Teresa C.; Limbert, Edward; Silva, Susana N.The incidence of thyroid cancer (TC), particularly well-differentiated forms (DTC), has been rising and remains the highest among endocrine malignancies. Although ionizing radiation (IR) is well established on DTC aetiology, other environmental and genetic factors may also be involved. DNA repair single nucleotide polymorphisms (SNPs) could be among the former, helping in explaining the high incidence. To furth...