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Management of multidrug-resistant tuberculosis: main recommendations of the Bra...
Ballestero,Jaqueline Garcia de Almeida; Garcia,Juliana Masini; Bollela,Valdes Roberto; Ruffino-Netto,Antonio; Dalcolmo,Margareth Maria PrettiABSTRACT Over the years, various recommendations have been made in pursuit of controlling resistance to antituberculosis drugs, especially multidrug resistance, in Brazil. Given the importance of standardizing those recommendations, the aim of this study was to describe the main recommendations of the Brazilian guidelines, primarily those related to the treatment and follow-up of cases of tuberculosis. From Aug...
Sequential analysis as a tool for detection of amikacin ototoxicity in the trea...
Vasconcelos,Karla Anacleto de; Frota,Silvana Maria Monte Coelho; Ruffino-Netto,Antonio; Kritski,Afrânio LineuABSTRACT Objective: To investigate early detection of amikacin-induced ototoxicity in a population treated for multidrug-resistant tuberculosis (MDR-TB), by means of three different tests: pure-tone audiometry (PTA); high-frequency audiometry (HFA); and distortion-product otoacoustic emission (DPOAE) testing. Methods: This was a longitudinal prospective cohort study involving patients aged 18-69 years with a di...
The importance of audiometric monitoring in patients with multidrug-resistant t...
Vasconcelos,Karla Anacleto de; Frota,Silvana Maria Monte Coelho; Ruffino-Netto,Antonio; Kritski,Afrânio LineuAbstract INTRODUCTION: A total of 771 cases of multidrug-resistant tuberculosis (MDR-TB) were reported in Brazil in 2014. Treatment of MDR-TB with aminoglycosides can produce serious side effects such as permanent and irreversible hearing loss, which occurs in 5-64% of cases, and severely compromise patient quality of life. The goal of this research was to evaluate auditory and vestibular side effects in patien...
Coordenação da assistência à tuberculose: registro de dados e a implementação d...
Orfão,Nathalia Halax; Crepaldi,Nathalia Yukie; Brunello,Maria Eugênia Firmino; Andrade,Rubia Laine de Paula; Monroe,Aline AparecidaResumo O objetivo deste artigo é analisar fontes de registro da tuberculose (TB) antes e após a implantação do Sistema Informatizado para Registro da Assistência à TB em Ribeirão Preto (SP). Estudo epidemiológico descritivo-analítico, do tipo intervenção. Os dados foram coletados em fontes secundárias, a partir de um formulário estruturado, e analisados através de teste Qui-quadrado ou Exato de Fisher com nível...
Tuberculosis control program in the municipal context: performance evaluation
Arakawa,Tiemi; Magnabosco,Gabriela Tavares; Andrade,Rubia Laine de Paula; Brunello,Maria Eugenia Firmino; Monroe,Aline Aparecida; Ruffino-Netto,AntonioABSTRACT OBJECTIVE The objective of this study is to evaluate the performance of the Tuberculosis Control Program in municipalities of the State of São Paulo. METHODS This is a program evaluation research, with ecological design, which uses three non-hierarchical groups of the municipalities of the State of São Paulo according to their performance in relation to operational indicators. We have selected 195 muni...
Frequency of indeterminate results from an interferon-gamma release assay among...
Oliveira,Sandra Maria do Valle Leone de; Trajman,Anete; Paniago,Anamaria Mello Miranda; Motta-Castro,Ana Rita Coimbra; Ruffino-Netto,AntonioABSTRACT Objective: To evaluate the frequency of and factors associated with indeterminate interferon-gamma release assay (IGRA) results in people living with HIV/AIDS (PLWHA). Methods: We tested 81 PLWHA in the central-west region of Brazil, using the tuberculin skin test and an IGRA. Information on sociodemographic and clinical variables was gathered through the use of questionnaires and from medical records....
Incidence of tuberculosis among patients with rheumatoid arthritis using TNF bl...
Yonekura,Claudia Leiko; Oliveira,Rene Donizeti Ribeiro; Titton,David C.; Ranza,Roberto; Ranzolin,Aline; Hayata,André L.; Duarte,Ângela; Silveira,Inês G.Abstract Objectives To assess the incidence of tuberculosis and to screen for latent tuberculosis infection among Brazilians with rheumatoid arthritis using biologics in clinical practice. Patients and methods This cohort study used data from the Brazilian Registry of Biological Therapies in Rheumatic Diseases (Registro Brasileiro de Monitoração de Terapias Biológicas - BiobadaBrasil), from 01/2009 to 05/2013, ...
Atrasos na suspeita e no diagnóstico de tuberculose e fatores relacionados
Sasaki,Natália Sperli Geraldes Marin dos Santos; Santos,Maria de Lourdes Sperli Geraldes dos; Vendramini,Silvia Helena F.; Ruffino-Netto,AntonioRESUMO: Objetivo: Medir os atrasos na suspeita e no diagnóstico de tuberculose (TB) e identificar fatores relacionados. Métodos: O atraso na suspeita foi definido como o tempo entre a percepção, pelo doente, dos sintomas até a procura pelo primeiro atendimento e no diagnóstico, como o tempo entre o primeiro atendimento até a realização do diagnóstico. Foram entrevistados 100 doentes, diagnosticados e notificado...
Magnitude da tuberculose pulmonar na população fronteiriça de Mato Grosso do Su...
Marques,Marli; Ruffino-Netto,Antonio; Marques,Ana Maria Campos; Andrade,Sonia Maria Oliveira de; Silva,Baldomero Antonio Kato daEste estudo analisou a magnitude da tuberculose pulmonar no período de 2007 a 2010 em municípios sul-mato-grossenses fronteiriços ao Paraguai e à Bolívia. Na região de fronteira, as taxas de incidência (49,1/100 mil habitantes), de mortalidade (4,0/100 mil) e de abandono do tratamento (11,3%) foram 1,6, 1,8 e 1,5 vez maiores do que na região não fronteiriça. Entre indígenas da fronteira, as taxas de incidência ...
Spatial distribution of the human development index, HIV infection and AIDS-Tub...
Rodrigues-Júnior,Antonio Luiz; Ruffino-Netto,Antonio; Castilho,Euclides Ayres deINTRODUCTION: AIDS epidemic has given visibility to the incidence of tuberculosis, for being the most frequent opportunistic infection. It is known that individuals who are socially vulnerable are more susceptible to HIV transmission and tuberculosis as well. OBJECTIVE: This study aims to conduct a geoepidemiological study on HIV/AIDS, AIDS-Tuberculosis co-infection and social vulnerability. METHOD: This is an ...