2 documents found, page 1 of 1
Living Proof of Activity of Extracellular Vesicles in the Central Nervous System
Mahjoum, Shadi; Rufino-Ramos, David; Almeida, Luís Pereira de; Broekman, Marike L. D.; Breakefield, Xandra O.; van Solinge, Thomas S.The central nervous system (CNS) consists of a heterogeneous population of cells with highly specialized functions. For optimal functioning of the CNS, in disease and in health, intricate communication between these cells is vital. One important mechanism of cellular communication is the release and uptake of extracellular vesicles (EVs). EVs are membrane enclosed particles actively released by cells, containin...
Mesenchymal stromal cells’ therapy for polyglutamine disorders: where do we sta...
Barros, Inês; Marcelo, Adriana; Silva, Teresa P.; Barata, João; Rufino-Ramos, David; Pereira de Almeida, Luís; Miranda, Catarina O.Polyglutamine (polyQ) diseases are a group of inherited neurodegenerative disorders caused by the expansion of the cytosine-adenine-guanine (CAG) repeat. This mutation encodes extended glutamine (Q) tract in the disease protein, resulting in the alteration of its conformation/physiological role and in the formation of toxic fragments/aggregates of the protein. This group of heterogeneous disorders shares common...