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Evaluating Efficacy of Antimicrobial and Antifouling Materials for Urinary Trac...

Madeleine Ramstedt; Isabel A. C. Ribeiro; Helena Bujdakova; Filipe J. M. Mergulhão; Luisa Jordão; Peter Thomsen; Martin Alm; Mette Burmølle

In Europe, the mean incidence of urinary tract infections in intensive care units is 1.1 per 1000 patient-days. Of these cases, catheter-associated urinary tract infections (CAUTI) account for 98%. In total, CAUTI in hospitals is estimated to give additional health-care costs of 1-2.5 pound billion in the United Kingdom alone. This is in sharp contrast to the low cost of urinary catheters and emphasizes the nee...


Continuous-flow precipitation as a route to prepare highly controlled nanohydro...

Filipa Castro; António Ferreira; Viviana P. Ribeiro; Ana L. Oliveira; Rui L. Reis; José A. Teixeira; Fernando Rocha

This work reports the biological evaluation of nanosized hydroxyapatite (HAp) previously synthesized by continuous-flow precipitation in a scaled-up meso oscillatory flow reactor (meso-OFR). Physicochemical characterization of the synthesized HAp suggests high surface reactivity namely because of its high specific surface area and low crystallinity. On the other hand, in vitro biomineralization assays demonstra...


Characterization of ulvan extracts to assess the effect of different steps in t...

Carina Costa; Anabela Alves; Paula C R. Pinto; Rui A. Sousa; Eduardo A. Borges da Silva; Rui L. Reis; Alírio E. Rodrigues

An effective application development of the polysaccharide ulvan requires a comprehensive knowledge about the influence of the extraction process on composition of the extracts and in ulvan itself. In this context, the two main objectives of the present work are (1) the establishment of an efficient extraction process for ulvan and (2) development of an accurate characterization methodology to evaluate the extr...


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