11 documents found, page 1 of 2
De novo human angiotensin - converting enzyme 2 Decoy NL-CVX1 protects mice fro...
Rebelo, Maria; Tang, Cong; Coelho, Ana R.; Labão-Almeida, Carlos; Schneider, Matthias M.; Tatalick, Laurie; Ruivo, Pedro; de Miranda, Marta PiresThe emergence of novel variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) underscores the need to investigate alternative approaches to prevent infection and treat patients with coronavirus disease 2019. Here, we report the preclinical efficacy of NL-CVX1, a de novo decoy that blocks virus entry into cells by binding with nanomolar affinity and high specificity to the receptor-binding doma...
De novo human angiotensin-converting enzyme 2 decoy NL-CVX1 protects mice from ...
Rebelo, Maria; Tang, Cong; Coelho, Ana R; Labão-Almeida, Carlos; Schneider, Matthias M.; Tatalick, Laurie; Ruivo, Pedro; Pires de Miranda, MartaThe emergence of novel variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) underscores the need to investigate alternative approaches to prevent infection and treat patients with coronavirus disease 2019. Here, we report the preclinical efficacy of NL-CVX1, a de novo decoy that blocks virus entry into cells by binding with nanomolar affinity and high specificity to the receptor-binding doma...
Interplay between liver and blood stages of Plasmodium infection dictates malar...
Chora, Ângelo Ferreira; Marques, Sofia; Lisboa Gonçalves, Joana; Lima, Priscila; Gomes Da Costa, Daniel; Fernandez-Ruiz, Daniel; Marreiros, Maria InêsPlasmodium replicates within the liver prior to reaching the bloodstream and infecting red blood cells. Because clinical manifestations of malaria only arise during the blood stage of infection, a perception exists that liver infection does not impact disease pathology. By developing a murine model where the liver and blood stages of infection are uncoupled, we showed that the integration of signals from both s...
Cross Species Analysis and Comparison of Tumors in Dogs and Cats, by Age, Sex, ...
Pinello, Katia; Pires, Isabel; Castro, Ana Filipa; Carvalho, Paulo Tiago; Santos, Andreia; Matos, Augusto; Queiroga, Felisbina; Canadas-Sousa, AnaThe animal cancer burden is essential for the translational value of companion animals in comparative oncology. The present work aims to describe, analyze, and compare frequencies and associations of tumors in dogs and cats based on the Animal Cancer Registry created by Vet-OncoNet. With 9079 registries, regarding 2019 and 2020, 81% (n = 7355) belonged to dogs. In comparison, cats have a general one-year right ...
A potential atypical case of rabbit haemorrhagic disease in a dwarf rabbit
Abade Dos Santos, F.A.; Magro, Carolina; Carvalho, Carina L.; Ruivo, Pedro; Duarte, Margarida D.; Peleteiro, Maria C.ABSTRACT - Rabbit haemorrhagic disease (RHD) is a highly contagious infectious disease of European wild and domestic rabbits. Rabbit haemorrhagic disease virus (RHDV, GI.1) emerged in 1986 in Europe, rapidly spreading all over the world. Several genotypes of RHDV have been recognised over time, but in 2010, a new virus (RHDV2/RHDVb, GI.2) emerged and progressively replaced the previous RHDV strains, due to the ...
Type 2 diabetes progression differently affects endothelial function and vascul...
Melo, Bernardete F.; Prieto-Lloret, Jesus; Cabral, Marlene D.; Martins, Fatima O.; Martins, Inês B.; Sacramento, Joana F.; Ruivo, Pedro; Carvalho, TâniaType 2 diabetes (T2D) is associated with cardiovascular and pulmonary disease. How T2D affects pulmonary endothelial function is not well characterized. We investigated the effects of T2D progression on contractility machinery and endothelial function in the pulmonary and systemic circulation and the mechanisms promoting the dysfunction, using pulmonary artery (PA) and aorta. A high-fat (HF, 3 weeks 60% lipid-r...
Transection of the superior sagittal sinus enables bilateral access to the rode...
Dias, Marcelo; Marques-Morgado, Inês; Coelho, Joana E; Ruivo, Pedro; Lopes, Luisa V.; Remondes, MiguelStereotaxic access to brain areas underneath the superior sagittal sinus (SSS) is notoriously challenging. As a major drainage vessel, covering the whole extension of the sagittal fissure, the SSS impedes direct bilateral access to underlying regions for recording and stimulation probes, drug-delivery cannulas, and injection devices. We now describe a new method for transection and retraction of the SSS in rats...
A potential atypical case of rabbit haemorrhagic disease in a dwarf rabbit
Abade dos Santos, Fábio A.; Magro, Carolina; Carvalho, Carina L.; Ruivo, Pedro; Duarte, Margarida D.; Peleteiro, Maria C.Rabbit haemorrhagic disease (RHD) is a highly contagious infectious disease of European wild and domestic rabbits. Rabbit haemorrhagic disease virus (RHDV, GI.1) emerged in 1986 in Europe, rapidly spreading all over the world. Several genotypes of RHDV have been recognised over time, but in 2010, a new virus (RHDV2/RHDVb, GI.2) emerged and progressively replaced the previous RHDV strains, due to the lack of cro...
In vivo bio-distribution and toxicity evaluation of polymeric and lipid-based n...
Fonseca-Gomes, João; Loureiro, Joana A; Tanqueiro, Sara; Mouro, Francisco; Ruivo, Pedro; Carvalho, Tânia; Sebastião, Ana M; Diógenes, Maria JoséNanoparticles (NPs), as drug delivery systems, appear to be a promising tool for prolonged therapeutic strategies as they allow a controlled drug release over time. However, most of the studies found in the literature simply contemplate the use of a single or low number of dosages with low NPs concentrations. In the context of chronic diseases, like Alzheimer's disease, cancer or human immunodeficiency virus (H...
First description of a fatal equine infection with Halicephalobus gingivalis in...
Noiva, Rute; Ruivo, Pedro; Madeira de Carvalho, Luís; Fonseca, Constança; Fevereiro, Miguel; Carvalho, Paulo; Orge, Leonor; Monteiro, MadalenaABSTRACT - Halicephalobus gingivalisis a small saprophytic rhabditid nematode, represented only by females with a typicalrhabditoid oesophagus and one egg in the uterus, capable of infecting vertebrates. This opportunistic parasitepresent in the soil, manure and decaying humus, is thought to penetrate through previous injuries to the mouth,eyes and skin of horses and migrate to various organs. The brain is one ...